Application for NGFN-2
KG: Infection and Inflammation

SIPAGE
"From Pathogen-Induced Signatures to Therapeutic Target Gens: Comparative and Functional Analysis of the Inflammatory Response in Health and Disease"

Coordinators' publication lists

Professor Trinad Chakraborty

1. Chakraborty, T., Hain, T., Domann, E. (2000) Genome organization and the evolution of the virulence gene locus in Listeria species. Int J Med Microbiol. 290(2):167-74.

2. Paschen, A., Dittmar, K.E., Grenningloh, R., Rohde, M., Schadendorf, D., Domann, E., Chakraborty, T., Weiss, S. (2000). Human dendritic cells infected by Listeria monocytogenes: induction of maturation, requirements for phagolysosomal escape and antigen presentation capacity. Eur J Immunol. 30(12):3447-3456.

3. Pistor, S., Grobe, L., Sechi, A.S., Domann, E., Gerstel, B., Machesky, L.M., Chakraborty, T., Wehland, J. (2000). Mutations of arginine residues within the 146-KKRRK-150 motif of the ActA protein of listeria monocytogenes abolish intracellular motility by interfering with the recruitment of the Arp2/3 complex. J Cell Sci. 113:3277-87.

4. Domann, E., Hossain, H., Füssle, R., Chakraborty, T. (2000) Rapid and reliable detection of multidrug resistant Staphylococcus aureus (MRSA) by multiplex-PCR]. Dtsch Med Wochenschr. 125(19):613-8.

5. Darji, A., zur Lage, S., Garbe, A.I., Chakraborty, T., Weiss, S. (2000) Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier. FEMS Immunol Med Microbiol. 27(4):341-9.

6. Stentebjerg-Olesen, B., Chakraborty, T., Klemm, P. (2000). FimE-catalyzed off-to-on inversion of the type 1 fimbrial phase switch and insertion sequence recruitment in an Escherichia coli K-12 fimB strain. FEMS Microbiol Lett. Jan 15;182(2):319-325.

7. Glaser, P., Frangeul, L., Buchrieser, C., Rusniok, C., Amend, A., Baquero, F., Berche, P., Bloecker, H., Brandt, P., Chakraborty, T., Charbit, A., Chetouani, F., Couve, E., de Daruvar, A., Dehoux, P., Domann, E., Dominguez-Bernal, G., Duchaud, E., Durant, L., Dussurget, O., Entian, K.D., Fsihi, H., Portillo, F.G., Garrido, P., Gautier, L., Goebel, W., Gomez-Lopez, N., Hain, T., Hauf, J., Jackson, D., Jones, L.M., Kaerst, U., Kreft, J., Kuhn, M., Kunst, F., Kurapkat, G., Madueno, E., Maitournam, A., Vicente, J.M., Ng, E., Nedjari, H., Nordsiek, G., Novella, S., de Pablos, B., Perez-Diaz, J.C., Purcell, R., Remmel, B., Rose, M., Schlueter, T., Simoes, N., Tierrez, A., Vazquez-Boland, J.A., Voss, H., Wehland, J., Cossart, P. (2001) Comparative genomics of Listeria species. Science, 294, 849-852.

8. Hense, M., Domann, E., Krusch, S., Wachholz, P., Dittmar, K.E., Rohde, M., Wehland, J., Chakraborty, T. , Weiss, S. (2001). Eukaryotic expression plasmid transfer from the intracellular bacterium Listeria monocytogenes to host cells. Cell Microbiol, 3, 599-609.

9. Hossain, H., Chakraborty, T. (2001) [Prion diseases]. Anasthesiol Intensivmed Notfallmed Schmerzther, 36, 15-24.

10. McNally, A., Roe, A.J., Simpson, S., Thomson-Carter, F.M., Hoey, D.E., Currie, C., Chakraborty, T., Smith, D.G., Gally, D.L. (2001). Differences in levels of secreted locus of enterocyte effacement proteins between human disease-associated and bovine Escherichia coli O157. Infect Immun, 69, 5107-5114.

11. Rose, F., Zeller, S.-A., Chakraborty, T., Domann, E., Machleidt., Th., Krönke, M., Seeger, W., Grimminger, F., Sibelius, U. (2001). Human Endothelial Cell Activation and Mediator Release in Response to Listeria monocytogenes Virulence Factors. Infect. Immun. 69: 897-905.

12. Schubert, W.D., Gobel, G., Diepholz, M., Darji, A., Kloer, D., Hain, T., Chakraborty, T., Wehland, J., Domann, E., Heinz, D.W. (2001) Internalins from the human pathogen Listeria monocytogenes combine three distinct folds into a contiguous internalin domain. J Mol Biol, 312, 783-794.

13. Vazquez-Boland, J.A., Kuhn, M., Berche, P., Chakraborty, T., Dominguez-Bernal, G., Goebel, W., Gonzalez-Zorn, B., Wehland, J., Kreft, J. (2001). Listeria pathogenesis and molecular virulence determinants. Clin Microbiol Rev, 14, 584-640.

14. Weiss, S., Chakraborty, T. (2001) Transfer of eukaryotic expression plasmids to mammalian host cells by bacterial carriers. Curr Opin Biotechnol, 12, 467-472.

15. Domann, E., Deckert, M., Schluter, D., Chakraborty, T. (2002). Listeria monocytogenes: a model system to study invasion and spread of bacteria in the central nervous system. Curr Top Microbiol Immunol, 265:213-26

16. Repp, H., Pamukci, Z., Koschinski, A., Domann, E., Darji, A., Brockmeier, D., Chakraborty, T., Dreyer, F. (2002). Listeriolysin of Listeria monocytogenes forms Ca2+-permeable pores leading to Ca2+ oscillations. Cell Microbiol. Aug;4(8):483-91.

17. Krusch, S., Domann, E., Frings, M., Zelmer, A., Diener, M., Chakraborty, T., Weiss, S. (2002). Listeria monocytogenes mediated CFTR transgene transfer to mammalian cells. J Gene Med. Nov-Dec;4(6):655-67.

18. Schubert, W.-D., Urbanke, C., Ziehm, Th., Beier, V., Machner, M.P., Domann, E., Wehland, J., Chakraborty, T., Heinz, D.W. (2002). Structure of Internalin, a major invasion protein of Listeria monocytogenes, in complex with its human receptor E-Cadherin. Cell 111 (6): 825-836.

19. Stockinger, S., Materna, T., Stoiber, D., Bayr, L., Steinborn, R., Kolbe, T., Unger, H., Chakraborty, T., Levy, D.E., Muller, M., Decker, T. (2002). Production of type I IFN sensitizes macrophages to cell death induced by Listeria monocytogenes. J Immunol. Dec 1;169(11):6522-9.

20. Hauf, N., Chakraborty, T. (2003). Suppression of NF-kB activation and proinflammatory cytokine expression by Shiga Toxin producing Escherichia coli. J Immunol. Feb 15;170(4):2074-82.

21. Peters, C., Domann, E., Darbouche, A., Chakraborty, T., Mielke, M.E. (2003). Tailoring host immune responses to Listeria by manipulation of virulence genes - the interface between innate and acquired immunity. FEMS Immunol Med Microbiol. Apr 1;35(3):243-53.

22. Darji, A., Mohamed, W., Domann, E., Chakraborty, T. (2003) Induction of immune responses by attenuated isogenic mutant strains of Listeria monocytogenes. Vaccine. Jun 1; 21 Suppl 2:S102-9.

23. Hossain, H., Ansari, F., Schulz-Weidner, N., Wetzel, W.E., Chakraborty, T., Domann, E. (2003). Clonal identity of Candida albicans in the oral cavity and the gastrointestinal tract of pre-school children. Oral Microbiol Immunol. Oct;18(5):302-8.

24. Hauck, E.W., Domann, E., Hauptmann, A., Weidner, W., Chakraborty, T., Hossain, H.M. (2003). Prospective analysis of 16S rDNA as a highly sensitive marker for bacterial presence in Peyronie's disease plaques. J Urol. Nov;170(5):2053-6.

25. Carroll SA, Hain T, Technow U, Darji A, Pashalidis P, Joseph SW, Chakraborty T. (2003). Identification and characterization of a peptidoglycan hydrolase, MurA, of Listeria monocytogenes, a muramidase needed for cell separation. J Bacteriol. Dec; 185(23): 6801-8.

26. Culture-independent identification of pathogenic bacteria and polymicrobial infections in the genitourinary tract of renal transplant recipients. Domann, E., Hong, G., Imirzalioglu, C., Turschner, S., Kuhle, J., Watzel, C., Hain, T., Hossain, H., and Chakraborty, T. J Clin Microbiol. 2003 Dec;41(12):5500-10.

Professor Werner Seeger

1. Rosseau, S., J. Selhorst, K. Wiechmann, K. Leissner, U. Maus, K. Mayer, F. Grimminger, W. Seeger, and J. Lohmeyer. Monocyte migration through the alveolar epithelial barrier - adhesion molecule mechanisms and impact of chemokines. J. Immunol. 164(1):427-35, 2000.
2. Schermuly, R., A. Röhl, N. Weissmann, A. Ghofrani, C. Schudt, H. Tenor, F. Grimminger, W. Seeger, and D. Walmrath. Subthreshold doses of specific Phosphodiesterase Type 3 and 4 inhibitors enhance the pulmonary vasodilatroy response to nebulized prostacyclin with improvement of gas exchange. J. Pharmacol. Exp. Ther. 1:292(2):512-520, 2000.
3. Sibelius, U., U. Grandel, M. Buerke, D. Müller, L. Kiss, R. Braun-Dullaeus, W. Haberbosch, W. Seeger, and F. Grimminger. Staphylococcal a-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts - role of thromboxane generation. Circulation 101(1)78-85, 2000.
4. Grimminger, F., K. Mayer, L. Kiss, D. Walmrath, and W. Seeger. PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in a model of pulmonary microvascular leukostasis. Am. J. Physiol. (Lung) 278 (2): L268-275, 2000.
5. Hoeper, M., H. Olschewski, A. Ghofrani, H. Wilkens, J. Winkler, M. Borst, J. Niedermeyer, H. Fabel, W. Seeger. A comparison of the acute hemodynamic effects of inhaled nitric oxide and aerosolized iloprost in primary pulmonary hypertension. German PPH study group. J. Am. Coll. Cardiol. 35:176-182, 2000.
6. Schermuly, R., A. Günther, T. Schmehl, N. Weismann, A. Ghofrani, D. Walmrath, F. Grimminger, and W. Seeger. Differential impact of ultrasonically nebulized versus tracheally instilled surfactant on ventilation perfusion (VA/Q) mismatch in a model of acute lung injury. Am. J. Respir. Crit. Care Med. 161:152-159, 2000.
7. Günther, A., P. Mosavi, S. Heinemann, C. Ruppert, H. Muth, P. Markart, F. Grimminger, D. Walmrath, B. Temmesfeld-Wollbrück, and W. Seeger. Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia - comparison with the ARDS. Am. J. Respir. Crit. Care Med. 161:454-462, 2000.
8. Kiss, L., H. Schütte, K. Mayer, H. Grimm, W. Padberg, W. Seeger, and F. Grimminger. Synthesis of arachidonic acid-derived lipoxygenase and cytochrome P 450 products in the intact human lung vasculature. Am. J. Respir. Crit. Care Med. 161:1917-1923, 2000.
9. Olschewski, H., A. Ghofrani, T. Schmehl, J. Winkler, H. Wilkens, M. Höper, J. Behr, F.-X. Kleber, W. Seeger. Inhaled iloprost to treat severe pulmonary hypertension. An uncontrolled trial. German PPH study group. Ann. Intern. Med. 132(6):435-443, 2000.
10. Ermert, L., M. Ermert, M. Goppelt-Strübe, M. Merkle, H. R. Duncker, F. Grimminger, and W. Seeger. Rat pulmonary cyclooxygenase-2 expression in response to endotoxin challenge: differential regulation in the various types of cells in the lung. Am. J. Pathol. 156(4):1275-1287, 2000.
11. Ermert, L., M. Ermert, H.R.-Duncker, F. Grimminger, W. Seeger. In-situ localization and regulation of Thromboxane A2-synthase in normal rat and human lung tissue. Am. J. Physiol. 278 (4):744-53, 2000.
12. Ermert, M., M. Merkle, R. Mootz, F. Grimminger, W. Seeger, and L. Ermert. Endotoxin priming of the cyclooxygenase 2-thromboxane axis in isolated rat lungs. Am. J. Physiol. (Lung) 278(6):1195-1203, 2000.
13. Fink, L., T. Kinfe, M. Stein, L. Ermert, U. Stahl, W. Kummer, W. Seeger, R. M. Bohle. Immunostaining and laser-assisted cell picking for m RNA analysis. Lab. Invest. 80 (3): 327-33, 2000.
14. Günther, A., P. Mosavi, C. Ruppert, S. Heinemann, B. Temmesfeld-Wollbrück, H.-G. Velcovsky, H. Morr, F. Grimminger, D. Walmrath, and W. Seeger. Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease. Thromb. Haemost. 83:853-60, 2000.
15. Rose F., L. Kiss, F. Grimminger, K. Mayer, U. Grandel, W. Seeger, E. Bienek, and U. Sibelius. E. coli hemolysin-induced lipid mediator metabolism in alveolar macrophages: impact of eicosapentaenoic acid. Am. J. Physiol. (Lung) 279:100-109, 2000.
16. Maus, U., S. Herold, S. Rosseau, R. Schlingensiepen, K. Schlingensiepen, R. Maus, W. Seeger, J. Lohmeyer. Antisense oligomers for selective suppression of MCP-1 synthesis in human pulmonary endothelial cells. Antisense and Nucl. Acid Drug Develop., 10:185-193, 2000.
17. Rose, F., K.U. Heuer, U. Sibelius, S. Hombach, L. Kiss, W. Seeger, and F. Grimminger. Targeting lipopolysaccharide residues by the non-toxic polymyxin B nonapeptide sensitizes resistent to the bactericidal effect of human neutrophils. J. Infect. Dis., 182:191-199, 2000.
18. Schulz, R., S. Mahmoudi, K. Hattar, U. Sibelius, H. Olschewski, K. Mayer, W. Seeger, and F. Grimminger. Enhanced release of superoxide from polymorphnuclear neutrophils in obstructive sleep apnea. Am. J. Respir. Crit. Care Med., 162:566-570, 2000.
19. Klemm, A., T. Tschernig, L. Ermert, A. Althoff, M. Merkle, A. Gebert, M. Ermert, W. Seeger, R. Pabst. Blockade of leukocyte function associated antigen-1 (Lfa-a) decreases lymphocyte trapping in the normal pulmonary vasculature: studies in the isolated buffer-perfused rat lung. Clin. Exp. Immunol., 121:375-83, 2000.
20. Weissmann, N., R. Voswinckel, A. Tadic, T. Hardebusch, A. Ghofrani, R. Schermuly, W. Seeger, and F. Grimminger. NO-Dependent, but not NO-independent guanylate cyclase activation attenuates hypoxic vasoconstriction in rabbit lungs. Am. J. Respir. Cell Molec. Biol., 23:222-227, 2000.
21. Rosseau, S. , P. Hammerl, U. Maus, H.-D. Walmrath, H. Schütte, F. Grimminger, W. Seeger, and J. Lohmeyer. Phenotypic characterization of alveolar monocyte recruitment in acute respiratory distress syndrome. Am. J. Physiol., 279:25-35, 2000.
22. Weissmann, N., A. Tadic, J. Hänze, F. Rose, S. Winterhalder, M. Nollen, R. Schermuly, A. Ghofrani, W. Seeger, and F. Grimminger. Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H2O2?. Am. J. Physiol. (Lung) L 683 - 690, 2000.
23. Fink L., T. Kinfe, W. Seeger, L. Ermert, W. Kummer, R. M. Bohle. Immunostaining for cell picking and real-time mRNA quantification. Am. J. Pathol., 157:1459-1466, 2000.
24. Grandel, U., A. Blum, M. Heep, L. Fink, M. Buerke, H.-J. Kraemer, K. Mayer, R. M. Bohle, W. Seeger, F. Grimminger, and U. Sibelius. Endotoxin induced myocardial TNF-a synthesis depresses myocardial contractility of isolated rat hearts: evidence for a role of thromboxane and sphingosine production. Circulation, 102:2758-2764, 2000.
25. Schulz, R., D. Schmidt, A. Blum, X. Lopes-Ribeiro, C. Lücke, K. Mayer, H. Olschewski, W. Seeger, and F. Grimminger. Decreased plasma levels of nitric oxide derivatives in obstructive sleep apnea - response to CPAP therapy. Thorax, 55:1046-1051, 2000.
26. Schütte, H., M. Witzenrath, K. Mayer, N. Weissmann, A. Schell, S. Rosseau, W. Seeger, and F. Grimminger. The PDE inhibitor zaprinast enhances NO-mediated protection against vascular leakage in reperfused lungs. Am. J. Physiol. (Lung), L496-502, 2000.
27. Schulz, R., H. Olschewski, F. Grimminger, W. Seeger. Prävalenz von Schlaganfall und transitorischer ischämischer Attacke (TIA) bei obstruktive Schlaf-Apnoe: eine retrospektive Erhebung an 187 konsekutiven Patienten. Pneumologie 54:575-579, 2000.
28. Maus, U., S. Herold, H. Muth, S. Rosseau, R. Maus, L. Ermert, M. Ermert, N. Weissmann, W. Seeger, F. Grimminger, and J. Lohmeyer. Monocytes recruited into the alveolar air space of mice show a monocytic phenotype but upregulate CD 14. Am. J. Physiol. (Lung) 280:L58-L68, 2001.
29. Hattar, K., U. Sibelius, A. Bickenbach, E. Csernok, W. Seeger, and F. Grimminger. Subtreshold concentrations of anti-proteinase 3-antibodies specifically prime human neutrophils for fMLP-induced leukotriene synthesis and chemotaxis. J. Leukocyte Biol., 69:89-97, 2001.
30. Grandel, U., U. Sibelius, J. Schrickel, D. Schmidt, M. Buerke, L. Fink, E. Bournelis, M. Heep, K. Mayer, R. M. Bohle, W. Seeger, and F. Grimminger. Biosynthesis of constitutive nitric oxide synthase-derived nitric oxide attenuates coronary vasoconstriction and myocardial depression in a model of septic failure induced by Staphylococcus aureus a-toxin. Crit. Care Med.,29(1):1-7, 2001.
31. Ermert, L., A. Hocke, H.-R. Duncker, W. Seeger, and M. Ermert. Comparison of different detection methods in quantitative microdensitometry. Am. J. Pathol., 158(2): 407-417, 2001.
32. Schermuly, R., N. Weissmann, B. Enke, A. Ghofrani, W. Forssmann, F. Grimminger, W. Seeger, and D. Walmrath. Urodilatin, a natriuretic peptide stimulating particulate guanylate cyclase, and the phosphodiesterase 5 inhibitor dipyridamole attenuate experimental pulmonary hypertension - synergism upon co-application. Am. J. Respir. Cell. Mol. Biol. (2):219-25, 2001.
33. Rose, F., S.-A. Zeller, T. Chakraborty, E. Doman, T. Machleidt, M. Krönke, W. Seeger, F. Grimminger, and U. Sibelius. Human endothelial cell activation and mediator release in response to listeria monocytogenes virluence factors. Infect. Immun., 69(2):897-905, 2001.
34. Schmidt, R., U. Meier, M. Yabut, D. Walmrath, F. Grimminger, W. Seeger, and A. Günther. Alteration of fatty acid profiles in different pulmonary surfactant phospholipids in acute respiratory distress syndrome (ARDS) and severe pneumonia. Am. J. Respir. Crit. Care Med., 163:95-100, 2001.
35. Schütte, H., A. Löckinger, D. Walmrath, W. Seeger, and F. Grimminger. Protection against gas exchange abnormalities by pre-aerosolized PGE1, iloprost and nitroprusside in lung ischemia-reperfusion. Transplantation, 71:185-193, 2001.
36. Schermuly, R., A. Günther, M. Ermert, L. Ermert, A. Ghofrani, N. Weissmann, F. Grimminger, W. Seeger, and D. Walmrath. Co-nebulization of surfactant and urokinase restores gas exchange in perfused lungs with alveolar fibrin formation. Am. J. Physiol. (Lung) 280(4): L792-800, 2001.
37. Weissmann, N., S. Winterhalder, M. Nollen, R. Voswinckel, K. Quanz, A. Ghofrani, R. Schermuly, W. Seeger, and F. Grimminger. Nitric oxide and reactive oxygen species are involved in hypoxia-induced biphasic vasoconstriction of isolated rabbit lungs. Am. J. Physiol. (Lung), 280(4): L638-645, 2001.
38. Gessler, T., T. Schmehl, M. Höper, F. Rose, A. Ghofrani, H. Olschewski, F. Grimminger, and W. Seeger. Ultrasonic versus jet nebulization of iloprost in severe pulmonary hypertension. Eur. Resp. J., 17:14-19, 2001.
39. Maus, U., J. Huwe, R. Maus, W. Seeger, J. Lohmeyer. Alveolar JE/MCP-1 and endotoxin synergize to provoke lung cytokine upregulation, sequential neutrophil and monocyte influx and vascular leakage in mice. Am. J. Respir. Crit. Care Med., 1;164(3):406-11, 2001.
40. Bohle, R.M., E. Hartmann, T. Kinfe, L. Ermert, W. Seeger, L. Fink. Cell-type specific mRNA quantitation in non-neoplastic tissues after laser-assisted cell picking. Pathobiology, 68(4-5):191-195, 2001.
41. Maus, U., W. Seeger, and J. Lohmeyer. Impact of a phosphorothioate oligodeoxynucleotide MCP-1 on NF-kappaB, AP-1, SP1 and NF-kappaB, and AP-1 subunit composition in human pulmonary endothelial cells. Antisense Nucleic Acid Drug Dev. 11(1):59-64, 2001.
42. Ghofrani, A., M. Kohstall, N. Weissmann, T. Schmehl, R. Schermuly, W. Seeger, and F. Grimminger. Alveolar epithelial-barrier function in ventilated isolated perfused rabbit lungs. Am. J. Physiol. (Lung), 280(5):L896-L904, 2001.
43. Hattar, K., L. Fink, K. Fietzner, B. Himmel, F. Grimminger, W. Seeger, and U. Sibelius. Cell density regulates neutrophil il-8 synthesis: role of il-1 receptor antagonist and soluble tnf receptors. J. Immunol., 166:6287-93, 2001.
44. Schütte, H., K. Mayer, H. Burger, M. Witzenrath, T. Gessler, W. Seeger, and F. Grimminger. Endogenous nitric oxide synthesis and vascular leakage in ischemic-reperfused rabbit lungs. Am. J. Respir. Crit. Care Med., 1;164(3):412-8, 2001.
45. Schütte, H., A. Löckinger, W. Seeger, and F. Grimminger. Aerosolized PGE1, PGI2 and nitroprusside protect against vascular leakage in lung ischemia-reperfusion. Eur. Respir. J., 18:15-22, 2001.
46. Wiedemann, R., A. Ghofrani, N. Weissmann, R. Schermuly, K. Quanz, F. Grimminger, W. Seeger, and H. Olschewski. Atrial Natriuretic Peptide in severe primary and secondary pulmonary hypertension. Response to iloprost inhalation. J. Am. Coll. Cardiol., 38 (4), 1130-6, 2001.
47. Schütte, H., M. Witzenrath, K. Mayer, S. Rosseau, W. Seeger, and F. Grimminger. Short term preconditioning with inhaled nitric oxide protects rabbits lungs against ischemia-reperfusion injury. Transplantation, 72:1363-1370, 2001.
48. Schermuly, R., A. Röhl, N. Weissmann, A. Ghofrani, H. Leuchte, F. Grimminger, W. Seeger, D. Walmrath. Combination of nonspecific PDE inhibitors with inhaled prostacyclin in experimental pulmonary hypertension. Am. J. Physiol. 281(6):L1361-8, 2001.
49. Jörres, R. A., O. Holz, W. Zachgo, P. Timm, S. Koschyk, B. Müller, F. Grimminger, W. Seeger, F. J. Kelly, C. Dunster, T. Frischer, G. Lubec, M. Waschewski, A. Niendorf, H. Magnussen. The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. Am. J. Respir. Crit. Care Med. 161(6):1855-61, 2001.
50. Schermuly, R., E. Krupnik, H. Tenor, C. Schudt, N. Weissmann, F. Rose, F. Grimminger, W. Seeger, D. Walmrath, and A. Ghofrani. Coaerosolization of Phosphodiesterase Inhibitors Markedly Enhances the Pulmonary Vasodilatory Response to Inhaled Iloprost in Experimental Pulmonary Hypertension. Maintenance of lung selectivity. Am. J. Respir. Crit. Care Med., 164(9):1694-1700, 2001.
51. Schulz, R., W. Seeger, F. Grimminger, M. Ip, W. Lam. Serum nitrite/nitrate levels in obstructive sleep apnea. Am. J. Respir. Crit. Care Med. 164(10):1997A-11997, 2001.
52. Fink, L., S. Kohlhoff, M. Stein, J. Hänze, N. Weissmann, F. Rose, E. Akkayagil, D. Manz, F. Grimminger, W. Seeger, R. M. Bohle. cDNA array hybridization after laser-assisted microdissection from nonneoplastic tissue. Am. J. Pathol. 160(1): 81-90, 2002.
53. Maus, U., J. Huwe, L. Ermert, M. Ermert, W. Seeger, J. Lohmeyer. Molecular pathways ,of monocyte emigration into the alveolar air space of intact mice. Am. J. Respir. Crit. Care Med., 165:95-100, 2002.
54. Schulz, R., C. Hummel, S. Heinemann, W. Seeger, and F. Grimminger. Serum levels of vascular endothelial growth factor (VEGF) are elevated in patients with obstructive sleep apnea and severe night-time hypoxia. Am. J. Respir. Crit. Care Med., 165:67-70, 2002.
55. Rose, F., G. Dahlem, B. Guthmann, F. Grimminger, U. Maus, J. Hänze, N. Duemmer, U. Grandel, W. Seeger, and A. Ghofrani. Mediator generation and signaling events in alveolar epithelial cells attacked by Staphylococcus aureus a-toxin. Am. J. Physiol. Lung, 282:L207-14, 2002.
56. Buerke M., U. Sibelius, U. Grandel, U. Buerke, F. Grimminger, W. Seeger, J. Meyer, H. Darius. Staphylococcus aureus alpha toxin mediates polymorphonuclear leukocyte-induced vasoconstriction and endothelial dysfunction. Shock, 17(1):30-5, 2002.
57. Grandel U., M. Reutemann, L. Kiss, M. Buerke, L. Fink, E. Bournelis, M. Heep, W. Seeger, F. Grimminger, U. Sibelius. Staphylococcal [alpha]-toxin provokes neutrophil-dependent cardiac dysfunction: role of ICAM-1 and cys-leukotrienes. Am. J. Physiol. (Heart), 282(3):H1157-H1165, 2002.
58. Schmidt, R., W. Steinhilber, C. Ruppert, C. Daum, F. Grimminger, W. Seeger, and A. Günther. An ELISA technique for quantification of surfactant apoprotein (SP)-C in bronchoalveolar lavage fluid. Am. J. Respir. Crit. Care Med., 165(4):470-474, 2002.
59. Hänze J., D. Gronenberg, F. Rose, A. Hanisch, J. Dötsch, C. Peiser, W. Rascher, W. Seeger, A. Fischer, and F. Grimminger. Genomic organization and regulation of a human 7-helix transmembrane receptor which is specifically expressed in pulmonary epithelium and induced in hypoxia. Biochem. Biophys. Res. Commun., 291(1):160-5, 2002.
60. Hattar, K., U. Grandel, A. Bickenbach, A. Schwarting, W. J. Mayet, S. Jessen, W. Seeger, F. Grimminger, U. Sibelius. Interaction of antibodies to proteinase 3 (c-ANCA) with human renal tubular epithelial cells: impact on signaling events and inflammatory mediator generation. J. Immunol., 168(6):3057-64, 2002.
61. Janssen, B., M Rindermann, U. Barth, G. Miltenberger-Miltenyi, D. Mereles, A. Abushi, W. Seeger, W. Kübler, C. Bartram, E. Grünig. Primary pulmonary hypertension: Genetic heterogeneity and evidence for a second locus on 2q31-32. Chest, 121: 54-56, 2002.
62. Ghofrani A., R. Wiedemann, F. Rose, H. Olschewski, R. Schermuly, N. Weissmann, W. Seeger, F. Grimminger. Combination of oral sildenafil (Viagra) and inhaled iloprost in severe pulmonary hypertension. Ann. Intern. Med. 136(7):515-22, 2002.
63. Walmrath, D., F. Grimminger, D. Pappert, C. Knothe, U. Obertacke, A. Benzing, A. Günther, T. Schmehl, H. Leuchte, and W. Seeger. Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on gas exchange and hemodynamics. Eur. Resp. J., 19 :805-810, 2002.
64. Günther, A., R. Schmidt, J. Harodt, Th. Schmehl, D. Walmrath, C. Ruppert, F. Grimminger, and W. Seeger. Bronchoscopic administration of bovine natural surfactant in ARDS and septic shock: impact on biophysical and biochemical surfactant properties. Eur. Resp. J., 19 :797-804, 2002.
65. Schulz, R., G. Baseler, H. Olschewski, A. Ghofrani, F. Grimminger, W. Waas, H. Tillmanns, and W. Seeger. Nocturnal periodic breathing in patients with primary pulmonary hypertension and congestive heart failure - a comparative study. Eur. Respir. J., 19:658-663, 2002.
66. Ermert, M., C. Ruppert, A. Günther, H.-R. Duncker, W. Seeger, L. Ermert. Cell-specific nitric oxide synthase-isoenzyme expression and regulation in response to endotoxin in intact rat lungs. Lab. Invest., 82(4):425-41, 2002.
67. Maus, U., A. Koay, T. Delbeck, M. Mack, M. Ermert, L. Ermert, T. S. Blackwell, J. W. Christman, D. Schlöndorff, W. Seeger, J. Lohmeyer. Role of resident alveolar macrophages in leukocyte traffic into the bronchoalveolar space of intact mice. Am. J. Physiol. Lung Cell Mol. Physiol. 282:6:L1245-52, 2002.
68. Mayser P., K. Mayer, M. Mahloudjian, S. Benzing, H.J. Krämer, W.B. Schill, W. Seeger, and F. Grimminger. A double-blind, randomized, placebo-controlled trial of n-3 vVersus n-6 fatty acid-based lipid infusion in atopic dermatitis. J. Parenter. Enteral Nutr. 26:151-8, 2002.
69. Langleben D., B. Christman, R. Barst, V. Dias Pharm, N. Galiè, T. Higenbottam, M. Kneussel, L. Korducki, R. Naeje, A. Riedel, G. Simonneau, A. Hirsch, S. Rich, I. Robbins, R. Oudiz, M. McGoon, D. Badesch, R. Levy, S. Mehta, W. Seeger, M. Solèr. Effects of the Thromboxane synthetase inhibitor and receptor antagonist, Terbogrel, in patients with primary pulmonary hypertension. Am. Heart J. ,143(5):E4, 2002.
70. Ghofrani A., R. Wiedemann, N. Weissmann, R. Schermuly, F. Grimminger, W. Seeger, and H. Olschewski. Lung cGMP synthesis in response to nitric oxide inhalation in severe pulmonary hypertension - responder versus non-responder. Eur. Respir. J., 19:664-71, 2002.
71. Mayer, K., R. Schmidt, M. Muhly-Reinholz, T. Bögeholz, St. Gokorsch, F. Grimminger, and W. Seeger. In vitro mimicri of essential fatty acid deficiency in human endothelial cells by TNF-a-impact of v-3 versus v-6 fatty acids. J. Lipid Res., 43(6):944-51, 2002.
72. Hattar, K., A. Bickenbach, E. Csernok, S. Rosseau, U. Grandel, W. Seeger, F. Grimminger, U. Sibelius. Wegener's Granulomatosis: antiproteinase 3 antibodies induce monocyte cytokine and prostanoid release - role of autocrine cell activation. J. Leuk. Biol., 71:996-1004, 2002.
73. Ruppert C., R. Schmidt, F. Grimminger, Y. Suzuki, W. Seeger, C. M. Lehr, A. Gunther. Chemical Coupling of a Monoclonal Antisurfactant Protein-B Antibody to Human Urokinase for Targeting Surfactant-Incorporating Alveolar Fibrin. Bioconjug. Chem. 17;13(4):804-811, 2002.
74. Maus, U., K. von Grote, W. A. Kuziel, M. Mack, E. J. Miller, J. Cihak, M. Stangassinger, R. Maus, D. Schlöndorff, W. Seeger, and J. Lohmeyer. The role of CC chemokine receptor- 2 (CCR2) in alveolar monocyte and neutrophil immigration in intact mice. Am. J. Respir. Crit. Care Med. 166(3):268-73, 2002.
75. Olschewski, H., G. Simonneau, N. Galiè, T. Higenbottam, R. Naeije, L. J. Rubin, S. Nikkho, R. Speich, M. Höper, J. Behr, J. Winkler, O. Sitbon, W. Popov, A. Ghofrani, A. Manes, D. G. Kiely, R. Ewert, A. Meyer, P. A. Corris, M. Delcroix, M. Gomez-Sanchez, H. Siedentop, W. Seeger. Aerosolized Iloprost Randomized Study Group. Inhaled iloprost for severe pulmonary hypertension. New Engl. J. Med. 347(5):322-9, 2002.
76. Rose F., B. Guthmann, T. Tenenbaum, L. Fink, A. Ghofrani, N. Weissmann, P. Konig, L. Ermert, G. Dahlem, J. Haenze, W. Kummer, W. Seeger, F. Grimminger. Apical but not basolateral endotoxin preincubation protects alveolar epithelial cells against hydrogen peroxide-induced loss of barrier function - role of nitric oxide synthesis. J. Immunol., 169(3):1474-81, 2002.
77. Mayer, K., M. Merfels, M. Muhly-Reinholz, St. Gokorsch, S. Rosseau, J. Lohmeyer, N. Schwarzer, M. Krüll, N. Suttorp, F. Grimminger, and W. Seeger. w-3 Fatty acids suppress monocyte adhesion to human endothelial cells - role of endothelial PAF generation. Am. J. Physiol.(Heart Circ. Physiol.), 283(2):H811-8, 2002.
78. Maus U., S. Henning, H. Wenschuh, K. Mayer, W. Seeger, and J. Lohmeyer. Role of endothelial MCP-1 in monocyte adhesion to inflamed human endothelium under physiological flow. Am J Physiol Heart Circ Physiol. 283(6):H2584-9, 2002.
79. Mayer K., M. Merfels, M. Muhly-Reinholz, S. Gokorsch, S. Rosseau, J. Lohmeyer, N. Schwarzer, M. Krull, N. Suttorp, F. Grimminger, W. Seeger Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. Am J Physiol Heart Circ Physiol. 283(2):H811-8, 2002
80. Ghofrani, A., R. Wiedemann, F. Rose, R. Schermuly, H. Olschewski, N. Weissmann, A. Günther, D. Walmrath, W. Seeger, and F. Grimminger. Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet, 360: 895-900, 2002.
81. Ghofrani A. , F. Rose, H. Olschewski, R. Wiedemann. R. Schermuly, N. Weissmann, C. Schudt, H. Tenor, W. Seeger, and F. Grimminger. Amplification of the pulmonary vasodilatory response to inhaled iloprost by subtreshold phosphodiesterase 3/4 inhibition in severe pulmonary hypertension. Crit. Care Med. 30(11):2489-92, 2002.
82. Hippenstiel, S., M. Witzenrath, B. Schmeck, Hocke, A, Krisp, M, , M. Krüll, J Seybold, W. Seeger, W., Rascher, H., Schütte and N. Suttorp. Adrenomedullin reduces endothelial hyperpermeability. Circ Res 4;91(7):618-25, 2002.
83. Rose F., F. Grimminger, J. Appel, M. Heller, V. Pies, N. Weissmann, L. Fink, S. Schmidt, St. Krick, G. Camenisch, M. Gassmann, W. Seeger, and J. Hänze. Hypoxic pulmonary artery fibroblasts trigger proliferation of vascular smooth muscle cells - role of hypoxia-inducible transcription factors. FASEB J. 16(12):1660-1, 2002.
84. Schmidt, R., U. Meier, F. Grimminger, H.G. Velcovsky, H. Morr, and W. Seeger, A. Günther. Altered fatty acid composition of lung surfactant phospholipids in interstitial lung disease. Am. J. Physiol. Lung Cell Mol. Physiol. 283(5):L1079-85, 2002.
85. Pruefer, D., J. Makowski, M. Schnell, M. Dahm, H. Oelert, U. Sibelius, U. Grandel, F. Grimminger, W. Seeger, S. Bhakdi, J. Meyer, H. Darius, M. Buerke. Simvastatin inhibits inflammatory properties of staphylococcus aureus a-Toxin. Circulation. 15;106(16):2104-10, 2002.
86. Schermuly, R., A. Schulz, A. Ghofrani, F. Rose, A. Roehl, N. Weissmann, A. Meidow, M. Hildebrand, J. Kurz, F. Grimminger, D. Walmrath, and W. Seeger. Pharmacokinetics and metabolism of infused versus inhaled iloprost in isolated rabbit lungs. J. Pharmacol. Exp. Ther., 303(2): 741-745, 2002.
87. Sibelius U., K. Hattar, S. Hoffmann, K. Mayer, U. Grandel, A. Schenkel, W. Seeger, F. Grimminger. Distinct pathways of LPS priming of human neutrophil respiratory burst: role of lipid mediator synthesis and sensitivity of IL-10. Crit. Care. Med., 30(10):2306-2312, 2002.
88. Schulz, R., C. Fegbeutel, N. Hackstein, W.Seeger. Obstructive sleep apnoea secondary to superior vena cava thrombosis in a patient with activated protein C resistance. Somnologie 6:173-175, 2002.
89. Janssen, B., M. Rindermann, U. Barth, G. Miltenberger-Miltenyi, D. Mereles, A. Abushi, W. Seeger, W. Kübler, C. R. Bartram, E. Grünig. Linkage Analysis in a Large Family with primary pulmonary hypertension: Genetic heterogeneity and a second primary pulmonary hypertension locus on 2q31-32. Chest, 121: 54S-56S, 2002.
90. Dailey, L. A., Schmehl, T. Gessler, T., Wittmar, M., Grimminger, F., Seeger, W. Kissel, T. Nebulization of biodegradable nanoparticles: impact of nebulizer technology and nanoparticle characteristics on aerosol features. J. Control Release, 9;86(1):131-44, 2003
91. Ruppert, C., C. Pucker, P. Markart, R. Schmidt, F. Grimminger, W. Seeger, J. Stürzebecher, and A. Günther. Selective inhibition of large-to-small aggregate conversion by serine protease inhibitors of the bis-benzamidine type. Am. J. Respir. Cell Molec Biol. 28(1):95-102, 2003.
92. Markart, P., C. Ruppert, F. Grimminger, W. Seeger, and A. Günther. The fibrinolysis-inhibitory capacity of clot-embedded surfactant is enhanced by SP-B and SP-C, but reduced by SP-A. Am. J. Physiol. Lung Cell. Mol. Physiol. 284(1):L69-76, 2003.
93. Friedrich, B., R. Schmidt, I. Reiss, A. Günther, W. Seeger, M. Müller, J. Thul, D. Schranz, L. Gortner. Changes in biochemical and biophysical surfactant properties with cardiopulmonary bypass in children. Crit. Care Med. 31:284-90, 2003.
94. Ruppert, C., R. Schmidt, P. Markart, F. Grimminger, W. Seeger, C. M. Lehr, and A. Günther. Chemical crosslinking of urokinase to pulmonary surfactant protein B results for targeting alveolar fibrin. Thromb Haemost. 89:53-64, 2003.
95. Sibelius U., U. Grandel, M. Buerke, L. Kiss, P. Klingenberger, M. Heep, E. Bournelis, W. Seeger, and F. Grimminger. Leukotriene-mediated coronary vasoconstriction and loss in myocardial contractility evoked by low doses of Eschericia coli hemolysin in perfused rat hearts. Crit. Care Med., Mar;683-688, 2003.
96. Schulz, R., C. Fegbeutel, A. Althoff, , H. Traupe, F. Grimminger, and W. Seeger. Central sleep apnoea and unilateral diaphragmatic paralysis associated with vertebral artery compression of the medulla oblongata. J Neurol, Apr.;250:503-505, 2003.
97. Schütte, H., A. Schell, Ch. Schäfer, A. Ghofrani, R. T. Schermuly, W. Seeger, F. Grimminger. Subtreshold doses of nebulized prostacyclin and rolipram synergistically protect against lung ischemia-reperfusion injury. Transplantation Mar. 27;75(6):814-821, 2003.
98. Ruppert, C., C. Pucker, P. Markart, K. Seibold, A. Bagheri, F. Grimminger, W. Seeger, A. Günther. Impact of surface tension on the conversion rate of large to small surfactant aggregates. Biophys. Chem. May 1;104(1):229-238, 2003.
99. Ghofrani, H. A., R. T. Schermuly, F. Rose, R. Wiedemann, M. G. Kohstall, A. Kreckel, H. Olschewski, N. Weissmann, B. Enke, S. Ghofrani, W. Seeger, F. Grimminger. Sildenafil for long-term treatment of nonoperable chronic thromboembolic pulmonary hypertension. Am. J. Respir. Crit. Care. Med. Apr. 15;167(8):1139-1141, 2003.
100. Ermert, M., D. Kuttner, N. Eisenhardt, C. Dierkes, W. Seeger, and L. Ermert. COX-2 and thromboxane dependent vascular and bronchial responses are regulated via p38 MAPK in control and endotoxin-primed rat lungs. Lab. Invest. 83(3):333-347, 2003.
101. Ermert, M., D. Kuttner, N. Eisenhardt, C. Dierkes, W. Seeger, L. Ermert. Cyclooxygenase-2-dependent and thromboxane-dependent vascular and bronchial responses are regulated via p38 mitogen-activated protein kinase in control and endotoxin-primed rat lungs. Lab Invest. Mar.;83(3):333-347, 2003.
102. Ermert M., C. Pantazis, H.-R. Duncker, F. Grimminger, W. Seeger, L. Ermert. In-situ localization of TNFa/b, Tace and the TNF receptors TNF-R1 and TNF-R2 in control and LPS-treated lung tissue. Cytokine May 22(3-4):89-100, 2003.
103. Weissmann, N., M. Nollen, B. Gerigk, A. Ghofrani, R. Schermuly, A. Günther, K. Quanz, L. Fink, J. Hänze, F. Rose, W. Seeger, and F. Grimminger. Downregulation of hypoxic vasoconstriction by chronic hypoxia in rabbit: effects of nitric oxide. Am. J. Physiol: HCP, 284:H931-8, 2003.
104. Voswinckel, R., T. Ziegelhoeffer, M. Heil, S. Kostin, G. Breier, T. Mehling, R. Haberberger, M. Clauss, A. Gaumann, W. Schaper, W. Seeger. Circulating vascular progenitor cells do not contribute to compensatory lung growth. Circ. Res. Aug. 22;93(4):372-379, 2003.
105. Mayer, K., C. Fegbeutel, K. Hattar, U. Sibelius, H. J. Krämer, K.-U. Heuer, B. Temmesfeld-Wollbrück, S. Gokorsch, W. Seeger, and F. Grimminger. w-3-versus w-6-lipid emulsions exert differential influence on neutrophil functions in septic shock patients. - Impact on plasma fatty acids and lipid mediator generation. Intensive Care Med. 29:1472-1481, 2003.
106. Ghofrani, HA, F. Rose, RT Schermuly, H. Olschewski, R. Wiedemann, A. Krekel, N. Weissmann, S. Ghofrani, B. Enke, W. Seeger, F. Grimminger Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension. J. Am. Coll. Cardiol. 42(1):158-164. 2003.
107. Maus U., K. Waelsch, W. Kuziel, T. Delbeck, M. Mack, T. Blackwell, J. Christman, D. Schlöndorff, W. Seeger, and J. Lohmeyer. Monocytes are potent facilitators of alveolar neutrophil emigration during lung inflammation: role of the CCL2-CCR2 axis. J. Immunol. Mar. 15;170(6):3273-327, 8, 2003.
108. Mayer, K., S. Gokorsch, C. Fegbeutel, K. Hattar, S. Rosseau, D. Walmrath, W. Seeger, and F. Grimminger. Parenteral nutrition with fish oil modulates cytokine response in septic patients. Am. J. Respir. Crit. Care Med. 167(10):1321-1328.2003.
109. Dailey, L.A., E. Kleemenn, M. Wittmar, G. Gessler, T. Schmehl, C. Roberts, W. Seeger, T. Kissel. Surfactant-Free, Biodegradable Nanoparticles for Aerosol Therapy Based on the Branched Polyesters, DEAPA-PVAL-g-PLGA. Pharmaceut Res,Vol.20, No. 12, 2011, 2003.
110. Hänze, J., B. G. Eul, R. Savai, S. Krick, P. Goyal, F. Grimminger, W. Seeger, F. Rose. RNA interference for HIF-a inhibits its downstream signalling and affects cellular proliferation. Biochem Biophys Res Comm, 312, 571-577, 2003.
111. Schermuly R., H. Leuchte, A. Ghofrani, N. Weissmann, F. Rose, M. Kostall, H. Olschewski, C. Schudt, F. Grimminger, W. Seeger, and D. Walmrath. Zardaverine and aerosolized iloprost in a model of acute respiratory failure. Eur. J. Respir. Aug. ;22 :342-347, 2003.
112. Mayer, K., C. Fegbeutel, K. Hattar, U. Sibelius, H. J. Kramer, K. U. Heuer, B. Temmesfeld-Wollbrück, S. Gokorsch, F. Grimminger, W. Seeger. Omega-3 vs. Omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipids mediator generation. Intensive Care Med. Sep.;29(9):1472-1481, 2003.
113. Schulz, R., J. Lohmeyer, W. Seeger. Obstructive sleep apnea due to HIV-associated lipodystrophy. Clin. Infect. Dis. Nov. 15;37(10):1398-1399, 2003.
114. Mayer, K., S. Meyer, M. Reinholz-Muhly, U. Maus, M. Merfels, J. Lohmeyer, F. Grimminger, and W. Seeger. Short-time infusion of fish-oil-based lipid emulsions, approved for parenteral nutrition, reduces monocyte proinflammatory cytokine generation and adhesive interaction with endothelium in humans. J. Immunol. Nov. 1;171(9) :4837-4843, 2003.
115. Rose. F., K. Hattar, S. Gakisch, F. Grimminger, H. Olschewski, W. Seeger, A. Tschuschner, R. Schermuly, N. Weissmann, J. Haenze, U. Sibelius, H.A. Ghofrani. Increased Neutrophil Mediator Release in Patients with Pulmonary Hypertension-Suppression by Inhaled Iloprost. Thromb Haemost, Dec.;90(6):1141-1149, 2003.
116. Günther, A., N. Lübke, M. Ermert, R. T. Schermuly, N. Weissmann, A. Breidhecker, P. Markart, C. Ruppert, K. Quanz, L. Ermert, F. Grimminger, and W. Seeger. Prevention of bleomycin-induced lung fibrosis by aerosolization of heparin or urokinase in rabbits. Am. J. Respir. Crit. Care Med. Dec. 1;168(11):1358-1365, 2003.
117. Weissmann, N., N. Ebert, M. Ahrens, A. Ghofrani, R. Schermuly, F. Rose, L. Fink, J. Hänze, J. Conzen, W. Seeger, and F. Grimminger. Effects of mitochondrial inhibitors and uncouplers on hypoxic vasoconstriction in intact rabbit lungs. Am. J. Respir. Cell Mol. Biol. Dec.;29(6):721-32, 2003.
118. Schulz, R., C. Fegbeutel, H. Olschewski, F. Rose, H. J. Schäfers, W. Seeger. Reversal of nocturnal periodic breathing in primary pulmonary hypertension - after lung transplantation. Chest Jan.;125(1):344-347, 2004.
119. Muth, H., U. Maus, M. Wygrecka, J. Lohmeyer, F. Grimminger, W. Seeger, A. Günther. Pro- and antifibrinolytic properties of human pulmonary microvascular versus artery endothelial cells: Impact of endotoxin and tumor necrosis factor-alpha. Crit. Care. Med. Jan.;32(1):217-226, 2004.
120. Schermuly, R., P. Kreiselmeier, H. A. Ghofrani, H. Yilmaz, H. Butrous, L. Ermert, M. Ermert, N. Weissmann, F. Rose, A. Günther, D. Walmrath, W. Seeger, F. Grimminger. Chronic sildenafil treatment inhibits monocrotaline-induced pulmonary hypertension in rats. Am. J. Respir. Crit. Care Med. Jan. 1;169(1):39-45, 2004.
121. Friedrich I., J. Boergermann, F. Splittgerber, M. Brinkmann, G. Bosniak, J.C. Reidemeister, R. E. Silber, W. Seeger, and A. Günther. Bronchoscopic surfactant administration preserves gas-exchange and pulmonary compliance after single lung transplantation in dogs. In Press: Thoracic Cardiovasc. Surg. 2004.
122. Günther, A., M. Balser, R. Schmidt, M. Yabut-Perez, A. Olk, J. Börgermann, F. Splittgerber, W. Seeger, and I. Friedrich. Surfactant abnormalities after single lung transplantation in dogs - impact of bronchoscopic surfactant administration. In Press: J. Thoracic Cardiovasc. Surg. 2004.
123. Weissmann, N., Akkayagil, e., Quanz, K., Schermuly, R. T., Ghofrani, H. A., Fink L., Haenze J., Rose F., Seeger W., Grimminger, F. Basic features of hypoxic pulmonary vasoconstriction in mice. In Press: Resp Physiol and Neurol., 2004.
124. Olschewski, H., B. Rohde, A. Heuner, B. Hanke, P. Jacobs, J. Behr, R. Ewert, T. Gessler, A. Ghofrani, T. Schmehl, W. Seeger. Pharmacodynamics and pharmacokinetics of inhaled iloprost, aerosolized by three different devices, in severe pulmonary hypertension. In revision: Chest 2004.
125. Grimm, H., S. Benzig, K. Mayer, F. Grimminger, W. Seeger, W. Fürst. Results of a multicenter study of a balanced lipid emulsion (SMOF) in patients after major abdominal surgery. In Revision: Clin. Nutr. 2004.
126. Grandel U., K. Hattar, G. Korosoglus, S. Morath, T. Hartung, K. Fietzner, M. Muhly-Reinholz, W. Seeger, F. Grimminger, and U. Sibelius. Lipoteichoic acid from Staphylococcus aureus primes the respiratory burst of human neutrophils-eivdence for a role of immunoglobulins and complement. In revision: Infect. Immun. 2004.
127. Schütte, H., T. Gessler, K. Mayer, J. Schlaudraff, M. Rühl, A. Ghofrani, W. Seeger, and F. Grimminger. Impact of mechanical forces on pulmonary nitric oxide generation - vascular shear stress versus vascular/alveolar distension. In revision: Am J Respir Crit. Care Med. 2004.
128. Muth, H., U. Maus, J. Lohmeyer, F. Grimminger, W. Seeger, and A. Günther. Fibrinolytic properties of human pulmonary artery versus microvasculatur endothelial cells - impact of endotoxin and TNF-a. In revision: Crit. Care Med. 2004.
129. Günther, A., N. Lübke, N. Weissmann, L. Ermert, Ch. Zoerb, R. Schermuly, K. Quantz, S. Heinemann, M. Ermert, F. Grimminger, and W. Seeger. Aerosolized bleomycin in rabbit lungs: acute lung injury and fibroproliferative response. In revision: Am J Respir Crit Care Med, 2004.
130. Sibelius, U., K. Hattar, C. Burgio, F. Rose, U. Grandel, L. Kiss, E. Bieniek, W. Seeger, and F. Grimminger. Downregulation of neutrophil inflammatory activity in dependence of cell densitiy: role of cell-bound PAF. In Revision: J Leukoc Biol, 2004.
131. Kiss, L., D. Vollmann, E. Bieniek, U. Grandel, M. Buerke, T. Chakraborty, W. Seeger, F. Grimminger, and U. Sibelius. Listeriolysin O is a potent inductor of eicosanoid generation, coronary vasoconstriction and myocardial depression in perfused rat hearts. In revision: Circulation, 2004.
132. Hänze J., P. Goyal, F. Grimminger, C. Hegel, L. Bader, F. Rose, , C. Hild, L. Fink, A. Ghofrani, R. Schermuly, H.H.H. Schmidt, W. Seeger, and N. Weissmann. Nox-1 is upregulated in hypoxia and stimulates HIF-1 dependent gene expression - role of reactive oxygen species. In revision: J Biol Chem, 2004.
133. Rose, F., A. Ghofrani, S. Sinis, L. Bur am Orde, L. Fink, R. Voswinkel, G. Dahlem, M. Kohstall, L. Ermert, M. Ermert, A. Jahn, J. Haenze, A. Günther, W. Seeger, and F. Grimminger. Influence of differentiation state and hypoxie on alveolar epithelial surfactant synthesis and chemokine secretion. In revision: Am J Crit Care Med, 2004.
134. Hattar, K., S. v. Bürck, A. Bickenbach, U. Grandel, E. Csernok, U. Maus, J. Lohmeyer, T. Hartung, W. Seeger, F. Grimminger, and U. Sibelius. Anti-proteinase (c-ANCA) prime CD14 dependent leukocyte activation. In Revision: J Leukoc Biol, 2004.

Professor Ingo Autenrieth

1. Autenrieth, I.B., and M. A. Schmidt. 2000. Bacterial interplay at intestinal mucosal surfaces: implications for vaccine development. Trends Microbiol., 8:457-464.
2. Hoerauf, A., L. Volkmann, K. Nissen-Pahle, C. Schmetz, I. Autenrieth, D. W. Buttner, B. Fleischer. 2000. Targeting of Wolbachia in Litomosoides sigmodontis: comparison of tetracycline with chloramphenicol, macrolides, and ciprofloxacin. Trop. Med. Int. Health. 5:275-279.
3. Schulte, R., G. Grassl, S. Preger, S. Fessele, C. A. Jacobi, M. Schaller, P. J. Nelson, I. B. Autenrieth. 2000. Yersinia enterocolitica invasin protein triggers IL-8 production via activation of Rel p65-p65 homodimers. FASEB J. 14:1471-1484.
4. Kampik, D., Schulte, R., I. B. Autenrieth. 2000. Yersinia enterocolitica invasin protein triggers differential production of IL-1, IL-8, MCP-1, GM-CSF, and TNF-? in epithelial cells: implications for understanding the early cytokine network in Yersinia infection. Infect. Immun. 68:2484-2492 .
5. Schulte, R., S. Kerneis, Klinke, S., H. Bartels, S. Preger, J.-P. Kraehenbuhl, E. Pringault, I. B. Autenrieth. 2000. Translocation of Yersinia enterocolitica across reconstituted intestinal epithelial monolayer is triggered by Yersinia invasin binding to ?1 integrins apically expressed on M-like cells. Cell. Microbiol. 2:173-186.
6. Schubert, S. and I. B. Autenrieth. 2000. Conjugation of hydroxylethylstarch to desferrioxamine (DFO) modulates the dual role of DFO in Yersinia enterocolitica infection. Clin. Diag. Lab. Immunol. 7:457-462.
7. Trebesius, K., L. Leitritz, K. Adler, S. Schubert, I. B. Autenrieth, J. Heesemann. 2000. Culture independent and rapid identification of bacterial pathogens in necrotizing fasciitis and streptococcal toxic shock syndrome by fluorescence in situ hybridization. Med. Microbiol. Immunol. 188:169-175.
8. Kempf, V.A.J., M. Schaller, I. Cakman, M. Aepfelbacher, I. B. Autenrieth. 2000. Interaction of Bartonella henselae with endothelial cells results in rapid bacterial rRNA synthesis and replication. Cell. Microbiol., 2:431-441.
9. Horneff, M., J. Reimann, A. Noll, Schirmbeck, R. I. B. Autenrieth. 2000. DNA vaccination using coexpression of cytokine genes and a bacterial gene encoding a 60 kDa heat shock protein. Med. Microbiol. Immunol. 189:97-104.
10. Hoerauf, A., L. Volkmann, C. Hamelmann, O. Adjei, I. B. Autenrieth, B. Fleischer. 2000. Endosymbiotic bacteria in worms as targets for a novel chemotherapy in filariasis. Lancet 355:1242-1243
11. Sing, A., E. Rauch, A. Roggenkamp, I. B. Autenrieth, J. Heesemann. 2000. Evaluation of the ICT Malaria PF test for rapid post-mortem diagnosis of Plasmodium falciparum malaria in corpses examined for forensic reasons. Int. J. Legal Med. 113:251-252.
12. Daniels, J.J., Autenrieth, I.B., Goebel. W. 2000. Interaction of Listeria monocytogenes with the intestinal epithelium. FEMS Microbiol. Lett. 15:323-328.
13. Rüssmann, H., V.A.J. Kempf, S. Koletzko, J. Heesemann, I. B. Autenrieth. 2001. Comparison of fluorescent in situ hybridization and conventional culturing for detection of Helicobacter pylori in gastric biopsy specimens. J. Clin. Microbiol., 39:304-308.
14. Konstantopoulos, N., Russmann, H., Tasch, C., Sauerwald, T., Demmelmann, H., Autenrieth, I., Koletzko, S. 2001. Evaluation of the Helicobacter pylori stool antigen test (HpSA) for detection of Helicobacter pylori infection in children. Am. J. Gastroenterol. 96: 677-683.
15. Kempf, V.A.J., Volkmann B., Schaller, M., Sander, C., Alitalo, K., Riess, T., I. B. Autenrieth. 2001. Evidence for a leading role of VEGF in Bartonella henselae-induced endothelial cell proliferations. Cell. Microbiol. 3: 623-632.
16. Derfuss, T., Gurkov, R., Bergh, FT., Goebels, N., Hartmann, M., Barz, C., Wilske, B., Autenrieth, I. B., Wick, M., Hohlfeld, R., Meinl, E. 2001. Intrathecal antibody production against Chlamydia pneumoniae in multiple sclerosis is part of a polyspecific immune response. Brain 124:1325-1335.
17. Wiedemann, A., Lindner, S., Grassl, G., Albert, M., I. B. Autenrieth, M. Aepfelbacher. 2001. Yersinia enterocolitica invasin triggers phagocytosis via beta1 integrins, CDC42Hs and WASp in macrophages. Cell. Microbiol. 3: 693-702.
18. Hein J, Sing A, Di Genaro MS, Autenrieth I. B. 2001. Interleukin-12 and interleukin-18 are indispensable for protective immunity against enteropathogenic Yersinia. Microb. Pathog. 2001 31:195-9.
19. Kempf, V.A., Petzold, H., I. B. Autenrieth. 2001. Cat scratch disease due to Bartonella henselae infection mimicking parotid malignancy. Eur. J. Clin. Microbiol. Infect. Dis. 20: 732-733.
20. Peschers, U.M., Kempf, V., Jundt, K., Autenrieth, I.B., T. Dimpfl. 2001. Antibiotic treatment to prevent urinary tract infection after urodynamic evaluation. Int. Urogynecol. J. Pelvic Floor Dysfunct. 12: 254-257.
21. Waidmann, M., Allemand, Y., Lehmann, J., di Genaro, S., Bücheler, N., Hamann, A., I. B. Autenrieth. 2002. Microflora-reactive IL-10-producing regulatory T cells are present in the colon of IL-2-deficient mice, but lack efficacious inhibition of IFN-gamma and TNF-alpha. Gut 50:170-179.
22. Kempf, V.A., Hitziger, N., Tiess, T., I. B. Autenrieth. 2002. Do plant and human pathogens have a common pathogenicity strategy? Trends Microbiol. 10: 269-275.
23. Carniel, E., Autenrieth, I. B., Cornelis, G., Fukushima, H., Guinet, F., Isberg, I., Pham, J., Prentice, M., Simonet, M., Skurnik, M., Wauters, G. 2002. Yersinia enterocolitica and Yersinia pseudotuberculosis. In: The Prokaryotes. Editors: M. Dworkin, S. Falkow, E. Rosenberg, K. H., Schleifer, E. Stackebrandt. Release 3.11, 3rd Edition. Springer, New York Inc.
24. Di Genaro, M.S., Waidmann, M., Kramer, U., Hitziger, N., Bohn, E., I. B. Autenrieth. 2003. Attenuated Yersinia enterocolitica mutant strains exhibit differential virulence in cytokine-deficient mice: implications for the development of novel live carrier vaccines. Infect. Immun. 71: 1804-1812.
25. Schumacher, U., I. B. Autenrieth. 2003. Tonsillitis. In: Encyclopedic references of molecular mechanisms of disease. Ed. F. Lang. Springer, in press
26. Kramer, U., Rizos, K., Apfel, H., I. B. Autenrieth, C. T. Lattemann. 2003. Autodisplay: development of an efficacious system for surface display of antigenic determinants in Salmonella vaccine strains. Infect. Immun. 71: 1944-1952.
27. Waidmann, M., O. Bechtold, J.S. Frick, H.A. Lehr, S. Schubert, U. Dobrindt, J. Löffler, E. Bohn, I. B. Autenrieth. 2003. Bacteroides vulgatus protects against Escherichia coli-induced colitis in gnotobiotic interleukin-2-deficient mice. Gastroenterology, 125:162-177.
28. Artz, L.A., Kempf, V.A.J., and I. B. Autenrieth.2003. Rapid screening for Streptococcus agalactiae in vaginal specimens of pregnant women by fluorescence in situ hybridization. J. Clin. Microbiol. 41: 2170-2173.
29. Grassl,G., Y. Müller, O. T. Bühler, E. Bohn, I. B. Autenrieth. 2003. Interaction of Yersinia enterocolitica with epithelial cells: invasin beyond invasion. Int. J. Med. Microbiol., 293:41-54.
30. Autenrieth, I.B. 2003. Mucosal immunity and microbial pathogenicity. Editorial. Int. J. Med. Microbiol., 293:1.
31. Grobusch, M.P., Kombila, M., Autenrieth, I.B., Mehlhorn, H., P.G. Kremsner. 2003. No evidence of Wolbachia endosymbiosis with Loa loa and Mansonella perstans. Parasitol. Res. 90:405-408.
32. Lauber, K., E. Bohn, SM Kröber, Y Xiao, S.G. Blumenthal, R. K. Lindemann, P. Marini, C. Wiedig, A. Zobywalski, S. Baksh, Y. Xu, I. B. Autenrieth, K. Schulze-Osthoff, C., Belka, G. Stuhler, S. Wesselborg. 2003. Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113:717-730 .
33. Becker, C., Wirtz, S., Blessing, M., Pirhonen, J., Strand, D., Bechtold, O., Frick, J., P.R. Galle, I.B.Autenrieth, M.F. Neurath. High constitutive IL-12 p40 promoter activity and IL-23 p19/p40 production in the terminal ileum of healthy mice mediated by lamina propria dendritic cells. J. Clin. Invest. 112:693-706.
34. Bohn, E., I. B. Autenrieth. 2003. Immune response to Yersinia. In: Molecular and Cellular Biology of Yersina. Ed. E. Carniel, J. Hinneush. Horizon Scientific Press/Calster
35. Grassl, G.A., M. Kracht, A. Wiedemann, E. Hofmann, M. Aepfelbacher, C. v. Eichel-Streiber, E. Bohn, I. B. Autenrieth. 2003. Activation of NF-kB and IL-8 by Yersinia enterocolitica invasin protein is conferred by engagement of Rac1 and MAP kinase cascades. Cell. Microbiol., in press.
36. Rieß, T., B. Anderson, A. Fackelmayer, I. B. Autenrieth, V. A. J. Kempf. 2003. Rapid and efficient transposon mutagenesis of Bartonella henselae by transposome technology. Gene. 313:103-109.
37. Autenrieth, I.B. 2003. Die Ökologie der humanen Darmflora: physiologische und pathophysiologische Aspekte. J. Gastrointest. Hepatol. Erkr. 1:14-17.
38. Bohn, E., Müller, S., Lauber, J., Geffers, R., Speer, N., Spieth, C., Krejci, J., Manncke, B., Buer, J., Zell, A., I. B. Autenrieth. 2004. Gene expression patterns of epithelial cells modulated by pathogenicity gfactors of Yersinia enterocolitica. Cell. Microbiol. 6:129-141.
39. Forschner, A., Autenrieth, I.B., Fierlbeck, G. 2004. Soft-tissue abscess caused by Salmonella enterica serovar Enteritidis at the site of melanoma metastasis. Clin. Microbiol. Infect. 10: 86-87.
40. Schuppler, M., Lötzsch, K., Waidmann, M., Autenrieth. I.B. 2004. High numbers of Escherichia coli harbored by the mucosa-associated bacterial flora of interleukin-2-defcient mice. Infect. Immun. in press.

Professor Ulrich Koszinowski

1. Mocikat R, Braumuller H, Gumy A, Egeter O, Ziegler H, Reusch U, Bubeck A, Louis J, Mailhammer R, Riethmuller G, Koszinowski U, Röcken M.: Natural killer cells activated by MHC class I(low) targets prime dendritic cells to induce protective CD8 T cell responses. Immunity. 19:561-9, 2003.

2. Campe H, Jaeger G, Abou-Ajram C, Nitschko H, Griebel M, Montoya C, Klare B, Koszinowski U.: Serial detection of Epstein-Barr virus DNA in sera and peripheral blood leukocyte samples of pediatric renal allograft recipients with persistent mononucleosis-like symptoms defines patients at risk to develop post-transplant lymphoproliferative disease. Pediatr Transplant. 7: 46-52, 2003

3. Cicin-Sain L., Brune W., Bubic I., Jonjic, St., Koszinowski UH.:
Vaccination of mice by bacteria carrying a cloned herpesvirus genome reconstituted in vivo. J. Virol. 77: 8249-8255, 2003

4. Mathys S, Schroeder T, Ellwart J, Koszinowski UH, Messerle M, Just U.: Dendritic cells under influence of mouse cytomegalovirus have a physiologic dual role: to Initiate and to restrict T cell activation. J. Infect Dis. 187:988-99, 2003.

5. Karrer U, Sierro S, Wagner M, Oxenius A, Hengel H, Koszinowski UH, Phillips R, Klenerman P.: Memory inflation: continuous accumulation of antiviral CD8+ T cells over time. J. Immunol. 170: 2022-29, 2003

6. Ménard C, Wagner M, Ruszics Z, Holak K, Brune W, Campbell AE, Koszinowski U.H.: Role of murine cytomegalovirus US22 gene family members for replication in macrophages. J. Virol. 77, 5557-5570, 2003

7. LoPiccolo DM, Gold MC, Kavanagh DG, Wagner M, Koszinowski UH, Hill AB.: Effective inhibition of K(b)- and D(b)-restricted antigen presentation in primary macrophages by murine cytomegalovirus. J. Virol. 77:301-8, 2003.

8. Lee BJ, Koszinowski UH, Sarawar SR, Adler H.: A gammaherpesvirus G protein-coupled receptor homologue is required for increased viral replication in response to chemokines and efficient reactivation from latency. J. Immunol. 170:243-51, 2003

9. Gold MC, Munks MW, Wagner M, Koszinowski UH, Hill AB, Fling SP.: The murine cytomegalovirus immunomodulatory gene m152 prevents recognition of infected cells by M45-specific CTL cell response in vivo. J. Immunol. 169: 359-65, 2002

10. Hahn, G, Khan, H, Baldanti, F, Koszinowski, U.H., Revello, M.G., Gerna, G.:
The human cytomegalovirus ribonucleotide reductase homolog UL45 is dispensable for growth in endothelial cells, as determined by a BAC-cloned clinical isolate of human cytomegalovirus with preserved wild-type characteristics. J. Virol. 76, 9551-9555, 2002

11. Reusch, U., Bernhard, O., Koszinowski, U.H., Schu, P.: AP-1A and AP-3A lysosomal sorting functions Traffic 3, 752-761, 2002

12. Stevenson, P.G., May, J.S., Smith, X.G., Marques, S., Adler, H., Koszinowski, U.H., Simas J.P., Efstathiou, S.:K3-mediated evasion of CD8+ T cells aids amplification of a latent g-herpesvirus. Nat. Immunol. 3:733-40, 2002

13. Krmpotic, A., Busch, D.H. Bubic, I., Gebhardt, F., Hengel, M.H., Scalzo, A.A., Koszinowski U.H., Jonjic, S.: MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo. Nat. Immunol. 3: 529-535, 2002

14. Wagner, M., Gutermann, A., Podlech J., Reddehase, M.J., Koszinowski, U.H.: MHC class I allele-specific cooperative and competitive interactions between immune evasion proteins of cytomegalovirus. J. Exp. Med., 196, 805-816, 2002

15. Muranyi, W.,Haas, J.,Wagner, M., Krohne, G., Koszinowski U.H.: Cytomegalovirus recruits cellular kinases to dissolve the nuclear lamina. Science 297, 854-857, 2002

16. Benz, Ch., Utermöhlen, O., Wulf, A., Villmow, B., Dries, V., Goeser, T., Koszinowski U.H., Busch, D.:Activated virus-specific T cells are early indicators of anti-CMV immune reactions in liver transplant patients. Gastroenterology 122:1201-15, 2002

17. Bubeck, A., Reusch, U., Wagner, M., Ruppert, Th., Muranyi, W. Kloetzel, P.M., Koszinowski U.H.: The Glycoprotein gp48 of Murine Cytomegalovirus: Proteasome-Dependent Cytosolic Dislocation and Degradation. J. Biol. Chem.: 277, 2216-2224, 2002

18. Brune, W., Hasan, M., Krych, M., Bubic, Jonjic, S., Koszinowski U.H.: Secreted virus-encoded proteins reflect murine cytomegalovirus productivity in organ. J. Infectious Diseases 184, 1320-1324, 2001

19. López, D., Samino, Y., Koszinowski U.H., Del Val M.: HIV envelope protein inhibits MHC class I presentation of a cytomegalovirus protective epitope. J. Immunol. 167, 4238-4244, 2001

20. Kavanagh, D.G., Koszinowski U.H., Hill Ann B.: The Murine Cytomegalovirus Immune Evasion Protein m4/gp34 Forms Biochemically Distinct Complexes with Class I MHC at the Cell Surface and in a Pre-Golgi Compartment. J. Immunol. 167, 3894-3902, 2001

21. Adler, Heiko, Messerle, Martin, Koszinowski, U. H.: Virus reconstituted from BAC-cloned murine gammaherpesvirus 68 acquires wildtype properties in vivo only after excision of BAC vector sequences. J. Virol., 75: 5692-96, 2001

22. Kavanagh, D. G., Gold, M. C., Wagner, M., Koszinowski, U. H., Hill, A. B.: The Multiple Immune-evasive Genes of Murine Cytomegalovirus Are Not Redundant: m4 and m152 Inhibit Antigen Presentation In a Complementary and Cooperative Fashion. J. Exp. Med. 194, 967-977, 2001

23. Kliche, S., Nagel,W., Kremmer, E., Atzler, C., Ege, A., Knorr, T. Koszinowski, U.H., Kolanus, W., Haas, J.: Signaling by Human Herpesvirus 8 Kaposin A Through Direct Membrane Recruitment of Cytohesin-1. Molecular Cell 7: 883-843, 2001

24. Brune W., Ménard C., Heesemann J., Koszinowski U.H.: A ribonucleotide reductase homolog of cytomegalovirus and endothelial cell tropism. Science 291: 303-305, 2001

25. Schwarz K., Eggers M., Koszinowski U.H., Kloetzel P.M., Groettrup M.: The proteasome regulator PA28a/b can enhance antigen presentation without affecting 20S proteasome subunit composition. Eur. J. Immunol. 30:3672-3679, 2000

26. Wagner M., Michel D., Messerle M., Schaarschmidt P., Vaida B., Jonjic St., Mertens Th., Koszinowski U.H.: Comparison between Human Cytomegalovirus pUL97 and Murine Cytomegalovirus (MCMV) pM97 Expressed by MCMV and Vaccinia Virus: pM97 Does Not Confer Ganciclovir Sensitivity. J. Virol. 74: 10729-10736, 2000

27. Hengel H., Reusch U., Geginat G., Holtappels R., Ruppert T., Hellebrand E., Koszinowski U.H.: Macrophages escape inhibition of major histocompatibility complex class I-dependent antigen presentation by cytomegalovirus. J.Virol. 74: 7861-7868, 2000

28. Hobom U., Brune W., Messerle M., Hahn G., Koszinowski U.H.: Fast screening procedures for random transposon libraries of cloned herpesvirus genomes: Mutational analysis of human cytomegalovirus envelope glycoprotein genes. J. Virol. 74: 7720-7729, 2000

29. Sijts A.J.A.M., Ruppert Th., Rehermann B., Schmidt M., Koszinowski U.H., Klötzel P-M.: Efficient generation of a Hepatitis B virus CTL epitope requires the structural features of immunoproteasomes. J.Exp.Med. 191, 503-514, 2000

30. Adler, H., Messerle M., Wagner M., Koszinowski U.H.: Cloning and mutagenesis of the murine gammaherpesvirus 68 genome as an infectious bacterial artificial chromosome. J. Virol. 74, 6964-6974, 2000

31. Stohwasser, R., Soza, A., Eggers, M., Koszinowski, U. H., Kloetzel, P.: P.M.(2000) PA28ab double und PA28b single transfectant mouse B8 cell lines reveal enhanced presentation of a mouse cytomegalovirus (MCMV) pp89 MHC class I epitope Molecular Immunology 37, 13-19, 2000

32. Ziegler H., Muranyi W., Burgert H.-G., Kremmer E., Koszinowski U.H.: The Luminal Part of Murine Cytomegalovirus gp40 catalyzes the Retention of MHC Class I Molecules. EMBO J. 19: 870-881, 2000

Professor Rolf Horstmann

1. Browne ENL, Frimpong E, Sievertsen J, Hagen J, Hamelmann C, Dietz K, Horstmann RD, Burchard GD (2000) Malariometric update for the rainforest and savanna of Ashanti region, Ghana. Ann Trop Med Parasitol. 94:15-22
2. Hamelmann C, Amedofu GK, Albrecht K, Muntau B, Gelhaus A, Brobby GW, Horstmann RD (2001) Pattern of connexin 26 (GJB2) mutations causing sensorineural hearing impairment in Ghana. Hum Mutat 18:84-85
3. Timmann C, Muntau B, Kühne K, Gelhaus A, Horstmann RD (2001) Two novel missense mutations R653H and E230K in the mediterranean fever gene associated with disease. Mutat Res 479:235-239
4. Gelhaus A, Scheding A, Browne E, Burchard GD, Horstmann RD (2001) Variability of the CD36 gene in West Africa. Hum Mutat 18:444-450
5. Brattig NW, Timmann C, Lepping B, Büttner DW, Marfo Y, Hamelmann C, Horstmann RD (2002) Onchocerca volvulus exposed persons fail to produce interferon-? in response to O. volvulus antigen but mount proliferative responses with interleukin-5 and -13 production that decrease with increasing microfilarial density. J Infect Dis 185:1148-1154
6. Meyer CG, Amedofu GK, Brandner J, Pohland D, Timmann C, Horstmann RD (2002) Selection for deafness? Nat Med 8:1332-1333
7. Thye T, Burchard GD, Nilius M, Müller-Myhsok B, Horstmann RD (2003) Genome-wide linkage analysis identifies polymorphism in the human interferon-y receptor affecting Helicobacter pylori infection. Am J Hum Genet 72:448-453
8. Horstmann RD (2003) Genetik der Empfänglichkeit und Resistenz gegenüber Tuberkulose. Der Internist 44:1385-1393
9. Hanotte O, Ronin Y, Agaba M, Nilsson P, Gelhaus A, Horstmann R, Sugimoto Y, Kemp S, Gibson J, Korol A, Soller M, Teale A (2003) Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. Proc Natl Acad Sci USA 100:7443-7448
10. Timmann C, Abraha RS, Hamelmann C, Büttner DW, Lepping B, Marfo Y, Brattig N, Horstmann RD (2003) Cutaneous pathology in onchocerciasis associated with pronounced systemic Th2 responses to Onchocerca volvulus. Br J Dermatol 149:782-787
11. Timmann C, Mersinli O, Kuhne K, Sievertsen J, Griebel MA, Dieckerhoff J, Horstmann RD (2003) Familial Mediterranean Fever with amyloidosis associated with novel exon 2 mutation (S179I) of the MEFV gene. Blood Cells Mol Dis 31:320-323
12. Marks F, Meyer CG, Sievertsen J, Timmann C, Evans J, Horstmann RD, May J (2004) Genotyping of Plasmodium falciparum pyrimethamine resistance by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Antimicrob Agents Chemother 48: 466-472
13. Gasmelseed NMA, Schmidt M, Magzoub MMA, Macharia M, Elmustafa OM, Ototo B, Winkler E, Ruge G, Horstmann RD, Meyer CG (2004) Low frequency of deafness-associated GJB2 variants in Kenya and Sudan, and novel GJB2 variants. Hum Mutat 23: 206-207

Professor Stefan Ehlers

1. Ehlers, S., S. Kutsch, E. M. Ehlers, J. Benini, and K. Pfeffer. 2000. Lethal granuloma disintegration in mycobacteria-infected TNFRp55-/- mice is dependent on T cells and interleukin-12. J. Immunol. 164: 2592-2601.
2. Ehlers S., and E. Richter. 2000. Interferon-gamma is essential for clearing Mycobacterium genavense infection. Infect. Immun. 68: 3720-3723.
3. Ehlers, S., N. Reiling, S. Gangloff, A. Woltmann, and S. M. Goyert. 2001. Mycobacterium avium infection in CD14-deficient mice fails to substantiate a significant role for CD14 in antimycobacterial protection or granulomatous inflammation. Immunology 103: 113-121.
4. Ehlers, S., and E. Richter. 2001. Differential requirement for IFN? to inhibit growth or eliminate some novel nontuberculous mycobacterial species in vivo. Clin. Exp. Immunol. 124: 229-238.
5. Ehlers, S., J. Benini, H. D. Held, C. Roeck, G. Alber and S. Uhlig. 2001. ?? T cell receptor-positive cells and interferon-?, but not inducible nitric oxide synthase, are critical for granuloma necrosis in a mouse model of mycobacteria-induced pulmonary immunopathology. J Exp Med. 194:1847-1859.
6. Ehlers S, Hölscher C, Scheu S, Tertilt C, Hehlgans T, Volz J, Endres R, Pfeffer K. 2003. The lymphotoxin-beta receptor is critically involved in controlling infections with the intracellular pathogens, Mycobacterium tuberculosis and Listeria monocytogenes. J. Immunol. 170:5210-18.
7. Peters, K., S. Leitzke, K. Borner, J. E. Diederichs, H. Hahn, R. H. Müller, and S. Ehlers. 2000. Preparation of a clofazimine nanosuspension for intravenous use and evaluation of ist therapeutic efficacy in murine Mycobacterium avium infection. J. Antimicrob. Chemother. 45: 1-7.
8. Lindhorst, T. K., M. Dubber, U. Krallmann-Wenzel, and S. Ehlers. 2000. Cluster-mannosides as inhibitors of type 1 fimbriae-mediated adhesion of Escherichia coli: Pentaerythritol derivatives as scaffolds. Eur. J. Org. Chem.: 2027-2034.
9. Lindhorst, T. K., S. Kötter, U. Krallmann-Wenzel, and S. Ehlers. 2001. Trivalent ?-D-mannoside clusters as inhibitors of type-1 fimbriae-mediated adhesion of Escherichia coli: structural variation and biotinylation. J. Chem. Soc. Perkin Trans. 1: 823-831.
10. Reiling, N., A. Blumenthal, H.-D. Flad, M.Ernst, and S. Ehlers. 2001. Mycobacteria-induced TNF and IL-10 formation by human macrophages is differentially regulated at the level of MAP kinase activity. J. Immunol. 167: 3339-3345.
11. Reiling, N., K. Klug, U. Krallmann-Wenzel, R. Laves, S. M. Goyert, M. E. Taylor, T. K. Lindhorst, and S. Ehlers. 2001. Complex encounters at the macrophage-mycobacterium interface: studies on the role of the mannose receptor and CD14 in experimental infection models with Mycobacterium avium. Immunobiology 204: 558-571.
12. Cooper, A. M., L. B. Adams, D. K. Dalton, R. Appelberg, and S. Ehlers. 2002. IFN-gamma and NO in mycobacterial disease: new jobs for old hands. Trends Microbiol. 10: 221-226.
13. Reiling N, Hölscher C, Fehrenbach A, Kröger S, Kirschning C, Goyert S, Ehlers S. 2002. Cutting edge: Toll like receptor (TLR) 2- and TLR4-mediated pathogen recognition in resistance to airborne infection with Mycobacterium tuberculosis. J Immunol 169: 3480-3484.
14. Dmitriev BA, Toukach FV, Schaper KJ, Holst O, Rietschel ET, Ehlers S. 2003. On the tertiary structure of bacterial murein: the scaffold model. J. Bact. 185: 3458-68.
15. Keller C, Lauber J, Buer J, Ehlers S. 2003. Resistance and susceptibility to tuberculosis analyzed at the transcriptome level: lessons from mouse macrophages. Tuberculosis, Microarray Special Issue, in press.
16. D'Souza, C. D., A. M. Cooper, A. A. Frank, S. Ehlers, J. Turner, A. Bendelac, and I. M. Orme. 2000. A novel nonclassical beta2-microglobulin-restricted mechanism influencing early lymphocyte accumulation and subsequent resistance to tuberculosis in the lung. Am. J. Resp. Cell. Mol. Biol. 23: 188-193.
17. Dmitriev, B. A., S. Ehlers, E. T. Rietschl, and P. J. Brennan. 2000. Molecular mechanics of the cell wall of mycobacteria: from horizontal layers to vertical scaffolds. Int. J. Med. Microbiol. 290: 251-258.
18. Cooper, A. M., J. E. Pearl, J. V. Brooks, S. Ehlers, and I. M. Orme. 2000. Expression of the NOS2 gene is not essential for early conrol of Mycobacterium tuberculosis in the murine lung. Infect. Immun. 68: 6879-82.
19. Müller, K., S. Ehlers, W. Solbach, and T. Laskay. 2001. Novel multi-probe RNAse protection assay sets for the detection of murine chemokine gene expression. J. Immunol. Methods 249: 155-165.
20. Pearl, J. E., B. Saunders, S. Ehlers, I. M. Orme, and A. M. Cooper. 2001. Inflammation and lymphocyte activation during mycobacterial infection in the interferon-gamma-deficient mouse. Cell. Immunol., 211: 43-50.
21. Wagner, J., R. Ignatius, S. Voss, V. Hopfner, S. Ehlers, G. Funke, U. Weber, and H. Hahn. 2001. Infection of the skin caused by Corynebacterium ulcerans and mimicking classical cutaneous diphtheria. Clin Infect Dis. 33:1598-600.
22. Blumenthal A, Ehlers S., Ernst M, Flad H-D, Reiling N. 2002. Control of mycobacterial replication in human macrophages: role of p38 and ERK1/2 MAP kinase pathways. Infect Immun 70: 4961-4967.
23. Seiler P, Aichele P, Bandermann S, Hauser AE, Lu B, Gerard NP, Gerard C, Ehlers S, Mollenkopf HJ, Kaufmann SH. 2003. Early granuloma formation after aerosol Mycobacterium tuberculosis infection is regulated by neutrophils via CXCR3-signaling chemokines. Eur J Immunol 33: 2676-2686.
24. Mailaender,C., N. Reiling, H. Engelhardt, S.Bossmann, S. Ehlers, and M. Niederweis. Porins play a key role forg rowth and antibiotic susceptibility of both Mycobacterium tuberculosis and Mycobacterium bovis BCG. Microbiology in press.
25. Sander, P., M. Rezwan, B. Walker, S. K. Rampini, R. Kroppenstedt, S. Ehlers, C. Keller, J.R. Keeble, M. Hagemeier, M. J. Colston, B. Springer, E.C. Böttger. 2004. Lipoprotein processing is required for virulence of Mycobacterium tuberculosis. Mol Microbiol, in press.
26. Göggel, R., S. Winoto-Morbach, G. Vielhaber, Y. Imai, K. Lindner, L. Brade, H. Brade, S. Ehlers, A.S. Slutsky, S. Schütze, E. Gulbins, S. Uhlig. 2004. PAF-mediated pulmonary edema: a novel effector function for acid sphingomyelinase and ceramide. Nat Med Jan 4 [Epub ahead of print]
27. Ehlers, S. 2000. Molekularbiologische Methoden in der mikrobiologischen Diagnostik. In: Infektionsmedizin in Gastroenterologie und Viszeralchirurgie, eds: Huchzermeyer/Lippert. Schattauer Verlag, Stuttgart, 1-18.
28. Ehlers, S, Lehmann J, Müller K, Laskay T, Buer J, Lauber J. 2002. Measuring immune responses in vivo. In Methods in Microbiology, Vol. 25 ( Immunology of Infection), 2nd edition, eds. Kaufmann SHE, Kabelitz D, 403-432.
29. Ehlers, S. Cytokines and chemokines in protective and inflammatory responses to infection with nontuberculous mycobacteria. In: Cytokines and Chemokines in Infectious Diseases Handbook (Ed. M. Kotb, T. Calandra), Humana Press Inc., Totowa NJ, p. 133-150.
30. Ehlers, S. 2003. The role of tumor necrosis factor (TNF) in tuberculosis: implications for therapeutic strategies targeting TNF. Ann Rheum Dis 62 Suppl 2: ii37-42.
31. Ehlers, S. 2003. Formalpathogenese der Tuberkulose: Mechanismen der Granulominduktion, -aufrechterhaltung, und -nekrose. Internist (Berl). 44: 1363-73
32. Ehlers, S. and Hölscher, C. Immunologie der Infektabwehr. In: Die Infektiologie, eds.: Adam/Doerr/Link/Lode, Springer Verlag, Heidelberg, p. 25-41
33. Hellmich B, Ehlers, S., Csernok E, Gross WL. 2003. Update on the pathogenesis of Churg-Strauss Syndrome. Clin. Exp. Rheumatol. 21: S69-77
34. Ehlers, S., Hölscher C. DTH-associated pathology. Topley and Wilson - Microbiology and Microbial Infections 10th edition (Immunology volume), Kaufmann S. and Steward M., Arnold Publishers, London; in press
35. Ehlers, S., Bulfone-Paus S. Shaping adaptive immunity to pathogens: the contribution of innate immune responses. In: Novel Vaccination Strategies (ed. SHE Kaufmann), VCH-Wiley, in press

Professor Gerd-Rüdiger Burmester

1 Burmester GR. Introduction. Rheumatology (Oxford) 2004;43 Suppl 1:I1-I3.
2 Bartholome B, Spies CM, Gaber T, Schuchmann S, Berki T, Kunkel D, Bienert M, Radbruch A, Burmester GR, Lauster R, Scheffold A,Buttgereit F. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and up-regulated after in vitro stimulation and in patients with rheumatoid arthritis. Faseb J 2004;18:70-80.
3 Schmitt B, Ringe J, Haupl T, Notter M, Manz R, Burmester GR, Sittinger M, Kaps C. BMP2 initiates chondrogenic lineage development of adult human mesenchymal stem cells in high-density culture. Differentiation 2003;71:567-77.
4 Kary S, Buttgereit F, Burmester GR. [In Process Citation]. Internist (Berl) 2003;44:951-8.
5 Haupl T, Ringe J, Erggelet C, Kaps C, Burmester GR, Sittinger M. [Tissue engineering: chances and challenges for application in rheumatic diseases]. Z Rheumatol 2003;62 Suppl 2:II46-II9.
6 van de Putte LB, Rau R, Breedveld FC, Kalden JR, Malaise MG, van Riel PL, Schattenkirchner M, Emery P, Burmester GR, Zeidler H, Moutsopoulos HM, Beck K, Kupper H. Efficacy and safety of the fully human anti-tumour necrosis factor alpha monoclonal antibody adalimumab (D2E7) in DMARD refractory patients with rheumatoid arthritis: a 12 week, phase II study. Ann Rheum Dis 2003;62:1168-77.
7 Priem S, Munkelt K, Franz JK, Schneider U, Werner T, Burmester GR, Krause A. [Epidemiology and therapy of Lyme arthritis and other manifestations of Lyme borreliosis in Germany: results of a nation-wide survey]. Z Rheumatol 2003;62:450-8.
8 Pirlich M, Schutz T, Kemps M, Luhman N, Burmester GR, Baumann G, Plauth M, Lubke HJ, Lochs H. Prevalence of malnutrition in hospitalized medical patients: impact of underlying disease. Dig Dis 2003;21:245-51.
9 Furst DE, Breedveld FC, Kalden JR, Smolen JS, Burmester GR, Dougados M, Emery P, Gibofsky A, Kavanaugh AF, Keystone EC, Klareskog L, Russell AS, van de Putte LB, Weisman MH,Kavenaugh AF. Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other immune mediated inflammatory diseases (May 2003). Ann Rheum Dis 2003;62 Suppl 2:ii2-9.
10 Stuhlmuller B, Kunisch E, Franz J, Martinez-Gamboa L, Hernandez MM, Pruss A, Ulbrich N, Erdmann VA, Burmester GR, Kinne RW. Detection of oncofetal h19 RNA in rheumatoid arthritis synovial tissue. Am J Pathol 2003;163:901-11.
11 Wollheim FA, Burmester GR. [In Process Citation]. Z Rheumatol 2003;62:406-8.
12 Feist E, Burmester GR, Dorner T. [B-cell depletion in the treatment of rheumatoid arthritis]. Z Rheumatol 2003;62:361-6.
13 Burmester GR. [In Process Citation]. Z Rheumatol 2003;62:353-4.
14 Egerer K, Hertzer J, Feist E, Albrecht A, Rudolph PE, Dorner T, Burmester GR. sE-selectin for stratifying outcome in rheumatoid arthritis. Arthritis Rheum 2003;49:546-8.
15 Krause MM, Brand MD, Krauss S, Meisel C, Vergin H, Burmester GR, Buttgereit F. Nonsteroidal antiinflammatory drugs and a selective cyclooxygenase 2 inhibitor uncouple mitochondria in intact cells. Arthritis Rheum 2003;48:1438-44.
16 Jacobi AM, Odendahl M, Reiter K, Bruns A, Burmester GR, Radbruch A, Valet G, Lipsky PE, Dorner T. Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum 2003;48:1332-42.
17 Lindenau S, Scholze S, Odendahl M, Dorner T, Radbruch A, Burmester GR, Berek C. Aberrant activation of B cells in patients with rheumatoid arthritis. Ann N Y Acad Sci 2003;987:246-8.
18 Kary S, Burmester GR. Anakinra: the first interleukin-1 inhibitor in the treatment of rheumatoid arthritis. Int J Clin Pract 2003;57:231-4.
19 Dorner T, Burmester GR. The role of B cells in rheumatoid arthritis: mechanisms and therapeutic targets. Curr Opin Rheumatol 2003;15:246-52.
20 Schultz O, Schuchmann S, Burmester GR, Buttgereit F. Case number 26: systemic idiopathic fibrosis associated with aortitis. Ann Rheum Dis 2003;62:486.
21 Fleischmann RM, Schechtman J, Bennett R, Handel ML, Burmester GR, Tesser J, Modafferi D, Poulakos J, Sun G. Anakinra, a recombinant human interleukin-1 receptor antagonist (r-metHuIL-1ra), in patients with rheumatoid arthritis: A large, international, multicenter, placebo-controlled trial. Arthritis Rheum 2003;48:927-34.
22 Kamradt T, Hansen G, Bechmann I, Burmester GR. [T-cell tolerance and autoimmunity]. Internist (Berl) 2003;44:146-52.
23 Loddenkemper K, Grauer A, Burmester GR, Buttgereit F. Calcium, vitamin D and etidronate for the prevention and treatment of corticosteroid-induced osteoporosis in patients with rheumatic diseases. Clin Exp Rheumatol 2003;21:19-26.
24 Feist E, Schneider ML, Brychcy M, Dorner T, Burmester GR, Hiepe F. A unique autoantibody pattern of positive anti-Jo-1, anti-U1RNP, and antiproteasome antibodies in autoimmune myositis as a diagnostic challenge. Ann Rheum Dis 2003;62:370-1.
25 Riemekasten G, Marell J, Hentschel C, Klein R, Burmester GR, Schoessler W,Hiepe F. Casein is an essential cofactor in autoantibody reactivity directed against the C-terminal SmD1 peptide AA 83-119 in systemic lupus erythematosus. Immunobiology 2002;206:537-45.
26 Riemekasten G, Langnickel D, Ebling FM, Karpouzas G, Kalsi J, Herberth G, Tsao BP, Henklein P, Langer S, Burmester GR, Radbruch A, Hiepe F, Hahn BH. Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies. Arthritis Rheum 2003;48:475-85.
27 Kuhnke A, Burmester GR, Krauss S, Buttgereit F. Bioenergetics of immune cells to assess rheumatic disease activity and efficacy of glucocorticoid treatment. Ann Rheum Dis 2003;62:133-9.
28 Ringe J, Kaps C, Burmester GR, Sittinger M. Stem cells for regenerative medicine: advances in the engineering of tissues and organs. Naturwissenschaften 2002;89:338-51.
29 Haupl T, Burmester GR, Stuhlmuller B. [New aspects of molecular biology diagnosis. Array technology and expression profile for characterization of rheumatic diseases]. Z Rheumatol 2002;61:396-404.
30 Dorner T, Burmester GR. [New laboratory diagnosis in rheumatology]. Z Rheumatol 2002;61:353-4.
31 Ruzickova S, Pruss A, Odendahl M, Wolbart K, Burmester GR, Scholze J, Dorner T,Hansen A. Chronic lymphocytic leukemia preceded by cold agglutinin disease: intraclonal immunoglobulin light-chain diversity in V(H)4-34 expressing single leukemic B cells. Blood 2002;100:3419-22.
32 Furst DE, Breedveld FC, Kalden JR, Smolen JS, Antoni CE, Bijlsma JW, Burmester GR, Cronstein B, Keystone EC, Kavanaugh A, Klareskog L. Updated consensus statement on biological agents for the treatment of rheumatoid arthritis and other rheumatic diseases (May 2002). Ann Rheum Dis 2002;61 Suppl 2:ii2-7.
33 Egerer K, Kuckelkorn U, Rudolph PE, Ruckert JC, Dorner T, Burmester GR, Kloetzel PM, Feist E. Circulating proteasomes are markers of cell damage and immunologic activity in autoimmune diseases. J Rheumatol 2002;29:2045-52.
34 Backhaus M, Burmester GR, Sandrock D, Loreck D, Hess D, Scholz A, Blind S, Hamm B,Bollow M. Prospective two year follow up study comparing novel and conventional imaging procedures in patients with arthritic finger joints. Ann Rheum Dis 2002;61:895-904.
35 Kaps C, Loch A, Haisch A, Smolian H, Burmester GR, Haupl T, Sittinger M. Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes. Med Biol Eng Comput 2002;40:485-90.
36 Dorner T, Siegenthaler W, Burmester GR. [Rheumatology on the move]. Dtsch Med Wochenschr 2002;127:1875.
37 Hansen A, Odendahl M, Reiter K, Jacobi AM, Feist E, Scholze J, Burmester GR, Lipsky PE, Dorner T. Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjogren's syndrome. Arthritis Rheum 2002;46:2160-71.
38 Riemekasten G, Weiss C, Schneider S, Thiel A, Bruns A, Schumann F, Blass S, Burmester GR, Hiepe F. T cell reactivity against the SmD1(83-119) C terminal peptide in patients with systemic lupus erythematosus. Ann Rheum Dis 2002;61:779-85.
39 Lunemann JD, Buttgereit F, Tripmacher R, Baerwald CG, Burmester GR, Krause A. Norepinephrine inhibits energy metabolism of human peripheral blood mononuclear cells via adrenergic receptors. Biosci Rep 2001;21:627-35.
40 Simon LS, Smolen JS, Abramson SB, Appel G, Bombardier C, Brater DC, Breedveld FC, Brune K, Burmester GR, Crofford LJ, Dougados M, DuBois RN, Fitzgerald GA, Frishman W, Garcia Rodriguez LA, Hochberg MC, Kalden JR, Laine L, Langman MJ, Prescott SM, van de Putte LB, Whelton A, White WB, Willaims GH. Controversies in COX-2 selective inhibition. J Rheumatol 2002;29:1501-10.
41 Buttgereit F, da Silva JA, Boers M, Burmester GR, Cutolo M, Jacobs J, Kirwan J, Kohler L, Van Riel P, Vischer T, Bijlsma JW. Standardised nomenclature for glucocorticoid dosages and glucocorticoid treatment regimens: current questions and tentative answers in rheumatology. Ann Rheum Dis 2002;61:718-22.
42 Lunemann JD, Buttgereit F, Tripmacher R, Baerwald CG, Burmester GR, Krause A. Effects of norepinephrine on oxygen consumption of quiescent and activated human peripheral blood mononuclear cells. Ann N Y Acad Sci 2002;966:365-8.
43 Jacobi AM, Hansen A, Kaufmann O, Pruss A, Burmester GR, Lipsky PE,Dorner T. Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjogren's syndrome. Arthritis Res 2002;4:R4.
44 Loddenkemper K, Perka C, Burmester GR, Buttgereit F. Coincidence of asymptomatic avascular necrosis and fracture of the femoral neck: a rare combination of glucocorticoid induced side effects. Ann Rheum Dis 2002;61:665-6.
45 Stroehmann A, Dorner T, Lukowsky A, Feist E, Hiepe F, Burmester GR. Cutaneous T cell lymphoma in a patient with primary biliary cirrhosis and secondary Sjogren's syndrome. J Rheumatol 2002;29:1326-9.
46 Riemekasten G, Ziemer S, Haupl T, Melzer C, Loddenkemper K, Hauptmann S, Burmester GR, Hiepe F. Shwartzman phenomenon in a patient with active systemic lupus erythematosus preceding fatal disseminated intravascular coagulation. Lupus 2002;11:204-7.
47 Ringe J, Kaps C, Schmitt B, Buscher K, Bartel J, Smolian H, Schultz O, Burmester GR, Haupl T, Sittinger M. Porcine mesenchymal stem cells. Induction of distinct mesenchymal cell lineages. Cell Tissue Res 2002;307:321-7.
48 Furst DE, Keystone EC, Breedveld FC, Kalden JR, Smolen JS, Antoni CE, Burmester GR, Crofford LJ, Kavanaugh A. Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis and other rheumatic diseases (April 2001). Ann Rheum Dis 2001;60 Suppl 3:iii2-5.
49 Kaps C, Bramlage C, Smolian H, Haisch A, Ungethum U, Burmester GR, Sittinger M, Gross G, Haupl T. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum 2002;46:149-62.
50 Smolian H, Thiele S, Kolkenbrock H, Zacher J, Aicher W, Schultz O, Burmester GR, Sittinger M. [Establishment of an in vitro model for rheumatoid arthritis as test system for therapeutical substances]. Altex 2001;18:265-80.
51 Smolian H, Aurer A, Sittinger M, Zacher J, Bernimoulin JP, Burmester GR, Kolkenbrock H. Secretion of gelatinases and activation of gelatinase A (MMP-2) by human rheumatoid synovial fibroblasts. Biol Chem 2001;382:1491-9.
52 Kaschner S, Hansen A, Jacobi A, Reiter K, Monson NL, Odendahl M, Burmester GR, Lipsky PE, Dorner T. Immunoglobulin Vlambda light chain gene usage in patients with Sjogren's syndrome. Arthritis Rheum 2001;44:2620-32.
53 Riemekasten G, Kawald A, Weiss C, Meine A, Marell J, Klein R, Hocher B, Meisel C, Hausdorf G, Manz R, Kamradt T, Burmester GR, Hiepe F. Strong acceleration of murine lupus by injection of the SmD1(83-119) peptide. Arthritis Rheum 2001;44:2435-45.
54 Jacobi AM, Rohde W, Ventz M, Riemekasten G, Burmester GR, Hiepe F. Enhanced serum prolactin (PRL) in patients with systemic lupus erythematosus: PRL levels are related to the disease activity. Lupus 2001;10:554-61.
55 Schmid D, Burmester GR, Tripmacher R, Fici G, von Voigtlander P, Buttgereit F. Short-term effects of the 21-aminosteroid lazaroid tirilazad mesylate (PNU-74006F) and the pyrrolopyrimidine lazaroid PNU-101033E on energy metabolism of human peripheral blood mononuclear cells. Biosci Rep 2001;21:101-10.
56 Pfueller B, Wolbart K, Bruns A, Burmester GR, Hiepe F. Successful treatment of patients with systemic lupus erythematosus by immunoadsorption with a C1q column: a pilot study. Arthritis Rheum 2001;44:1962-3.
57 Lubke C, Sittinger M, Burmester GR, Paulitschke M. Cryopreservation of artificial cartilage: viability and functional examination after thawing. Cells Tissues Organs 2001;169:368-76.
58 Burmester GR. [Molecular mechanisms of action of gold in treatment of rheumatoid arthritis--an update]. Z Rheumatol 2001;60:167-73.
59 Dorffel Y, Franz S, Pruss A, Neumann G, Rohde W, Burmester GR, Scholze J. Preactivated monocytes from hypertensive patients as a factor for atherosclerosis? Atherosclerosis 2001;157:151-60.
60 Backhaus M, Burmester GR, Gerber T, Grassi W, Machold KP, Swen WA, Wakefield RJ,Manger B. Guidelines for musculoskeletal ultrasound in rheumatology. Ann Rheum Dis 2001;60:641-9.
61 Blass S, Union A, Raymackers J, Schumann F, Ungethum U, Muller-Steinbach S, De Keyser F, Engel JM, Burmester GR. The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Arthritis Rheum 2001;44:761-71.
62 Wahle M, Kolker S, Krause A, Burmester GR, Baerwald CG. Impaired catecholaminergic signalling of B lymphocytes in patients with chronic rheumatic diseases. Ann Rheum Dis 2001;60:505-10.
63 Blass S, Engel JM, Burmester GR. [The immunologic homunculus in rheumatoid arthritis. A new viewpoint of immunopathogenesis in rheumatoid arthritis and therapeutic consequences]. Z Rheumatol 2001;60:1-16.
64 Gause A, Manger B, Kalden JR, Burmester GR. [Therapy of inflammatory rheumatic diseases: from current practice standards to future]. Internist (Berl) 2001;42:223-32, 34-6.
65 Lunemann JD, Zarmas S, Priem S, Franz J, Zschenderlein R, Aberer E, Klein R, Schouls L, Burmester GR, Krause A. Rapid typing of Borrelia burgdorferi sensu lato species in specimens from patients with different manifestations of Lyme borreliosis. J Clin Microbiol 2001;39:1130-3.
66 Franz JK, Fritze O, Rittig M, Keysser G, Priem S, Zacher J, Burmester GR, Krause A. Insights from a novel three-dimensional in vitro model of lyme arthritis: standardized analysis of cellular and molecular interactions between Borrelia burgdorferi and synovial explants and fibroblasts. Arthritis Rheum 2001;44:151-62.
67 Jacobi AM, Hansen A, Burmester GR, Dorner T, Lipsky PE. Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus. Autoimmunity 2000;33:61-76.
68 Buttgereit F, Burmester GR, Simon LS. Gastrointestinal toxic side effects of nonsteroidal anti-inflammatory drugs and cyclooxygenase-2-specific inhibitors. Am J Med 2001;110 Suppl 3A:13S-9S.
69 Jacobi AM, Rohde W, Volk HD, Dorner T, Burmester GR, Hiepe F. Prolactin enhances the in vitro production of IgG in peripheral blood mononuclear cells from patients with systemic lupus erythematosus but not from healthy controls. Ann Rheum Dis 2001;60:242-7.
70 Schultz O, Sittinger M, Haeupl T, Burmester GR. Emerging strategies of bone and joint repair. Arthritis Res 2000;2:433-6.
71 Kinne RW, Brauer R, Stuhlmuller B, Palombo-Kinne E, Burmester GR. Macrophages in rheumatoid arthritis. Arthritis Res 2000;2:189-202.
72 Schmid D, Burmester GR, Tripmacher R, Kuhnke A, Buttgereit F. Bioenergetics of human peripheral blood mononuclear cell metabolism in quiescent, activated, and glucocorticoid-treated states. Biosci Rep 2000;20:289-302.
73 Hundt M, Manger K, Dorner T, Grimbacher B, Kalden P, Rascu A, Weber D, Burmester GR, Peter HH, Kalden JR, Schmidt RE. Treatment of acute exacerbation of systemic lupus erythematosus with high-dose intravenous immunoglobulin. Rheumatology (Oxford) 2000;39:1301-2.
74 Baerwald CG, Burmester GR, Krause A. Interactions of autonomic nervous, neuroendocrine, and immune systems in rheumatoid arthritis. Rheum Dis Clin North Am 2000;26:841-57.
75 Odendahl M, Jacobi A, Hansen A, Feist E, Hiepe F, Burmester GR, Lipsky PE, Radbruch A, Dorner T. Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus. J Immunol 2000;165:5970-9.
76 Rosen O, Thiel A, Massenkeil G, Hiepe F, Haupl T, Radtke H, Burmester GR, Gromnica-Ihle E, Radbruch A, Arnold R. Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells. Arthritis Res 2000;2:327-36.
77 Furst DE, Breedveld FC, Burmester GR, Crofford JJ, Emery P, Feldmann M, Kalden JR, Kavanaugh AF, Keystone EC, Klareskog LG, Lipsky PE, Maini RN, Russell AS, Scott DL, Smolen JS, Van de Putte LB, Visher TL,Weisman MH. Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis (May 2000). Ann Rheum Dis 2000;59 Suppl 1:i1-2.
78 Bruns A, Blass S, Hausdorf G, Burmester GR, Hiepe F. Nucleosomes are major T and B cell autoantigens in systemic lupus erythematosus. Arthritis Rheum 2000;43:2307-15.
79 Egerer K, Feist E, Rohr U, Pruss A, Burmester GR, Dorner T. Increased serum soluble CD14, ICAM-1 and E-selectin correlate with disease activity and prognosis in systemic lupus erythematosus. Lupus 2000;9:614-21.
80 Perka C, Sittinger M, Schultz O, Spitzer RS, Schlenzka D, Burmester GR. Tissue engineered cartilage repair using cryopreserved and noncryopreserved chondrocytes. Clin Orthop 2000;245-54.
81 Burmester GR. [Scientific graduate education, sponsorship and research cooperation in the anti-corruption law tension field--effects on members of the German Society of Rheumatology]. Z Rheumatol 2000;59:162-71.
82 Haisch A, Groger A, Radke C, Ebmeyer J, Sudhoff H, Grasnick G, Jahnke V, Burmester GR, Sittinger M. Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation. Biomaterials 2000;21:1561-6.
83 Smolen JS, Breedveld FC, Burmester GR, Combe B, Emery P, Kalden JR, Klareskog L, Maini RN, Numo R, van De Putte LB, van Riel PL, Rodriguez-Valverde V. Consensus statement on the initiation and continuation of tumour necrosis factor blocking therapies in rheumatoid arthritis. Ann Rheum Dis 2000;59:504-5.
84 Perka C, Schultz O, Spitzer RS, Lindenhayn K, Burmester GR, Sittinger M. Segmental bone repair by tissue-engineered periosteal cell transplants with bioresorbable fleece and fibrin scaffolds in rabbits. Biomaterials 2000;21:1145-53.
85 Sanden S, Tripmacher R, Weltrich R, Rohde W, Hiepe F, Burmester GR, Buttgereit F. Glucocorticoid dose dependent downregulation of glucocorticoid receptors in patients with rheumatic diseases. J Rheumatol 2000;27:1265-70.
86 Stuhlmuller B, Ungethum U, Scholze S, Martinez L, Backhaus M, Kraetsch HG, Kinne RW, Burmester GR. Identification of known and novel genes in activated monocytes from patients with rheumatoid arthritis. Arthritis Rheum 2000;43:775-90.
87 Buttgereit F, Burmester GR,Brand MD. Bioenergetics of immune functions: fundamental and therapeutic aspects. Immunol Today 2000;21:192-9.
88 Steinbach F, Henke F, Krause B, Thiele B, Burmester GR, Hiepe F. Monocytes from systemic lupus erythematous patients are severely altered in phenotype and lineage flexibility. Ann Rheum Dis 2000;59:283-8.
89 Perka C, Schultz O, Lindenhayn K, Spitzer RS, Muschik M, Sittinger M, Burmester GR. Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices. Clin Exp Rheumatol 2000;18:13-22.
90 Kolkenbrock H, Zimmermann J, Burmester GR, Ulbrich N. Activation of progelatinase B by membranes of human polymorphonuclear granulocytes. Biol Chem 2000;381:49-55.
91 Buttgereit F, Burmester GR, Brand MD. Therapeutically targeting lymphocyte energy metabolism by high-dose glucocorticoids. Biochem Pharmacol 2000;59:597-603.
92 Haisch A, Groger A, Radke C, Ebmeyer J, Sudhoff H, Grasnick G, Jahnke V, Burmester GR, Sittinger M. [Protection of autogenous cartilage transplants from resorption using membrane encapsulation]. Hno 2000;48:119-24.

Professor Hermann Wagner

1. Bauer, M., H. Wagner, and G. B. Lipford. 2000. HPV type 16 protein E7 HLA-A2 binding peptides are immunogenic but not processed and presented. Imm.Lett. 71:55-59.
2. Dankesreiter, S., A. Hoess, J. Schneider-Mergener, H. Wagner, and T. Miethke. 2000. Synthetic endotoxin-binding peptides block endotoxin-triggered TNF-? production by macrophages in vitro and in vivo and prevent endotoxin-mediated toxic shock. J.Immunol. 164:4804-4811.
3. Decker, T., F. Schneller, T. Sparwasser, T. Tretter, G. B. Lipford, H. Wagner, and C. Peschel. 2000. Immunostimulatory CpG-oligonucleotides cause proliferation, cytokine production and an immunogenic phenotype in chronic lymphocytic leukemia B cells. Blood 95:999-1006.
4. Decker, T., F. Schneller, M. Krohnschnabel, T. Dechow, G. B. Lipford, H. Wagner, and C. Peschel. 2000. Immunostimulatory CpG-oligonucleotides induce functional high affinity IL-2 receptors on B-CLL cells: Costimulation with Il-2 results in a highly immunogenic phenotype. Exp.Haematology 28:558-568.
5. Hacker, H., R. M. Vabulas, O. Takeuchi, K. Hoshino, S. Akira, and H. Wagner. 2000. Immune Cell Activation by Bacterial CpG-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (TRAF)6. J.Exp.Med. 192:595-600.
6. Häcker, H. 2000. Signal transduction pathways activated by CpG-DNA. In Immunobiology of bacterial CpG-DNA, Vol. ´247. H. Wagner, ed. Springer Verlag, Heidelberg, pp. 77-92.
7. Hemmi, H., O. Takeuchi, T. Kawal, T. Kalsho, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nat 406:740-745.
8. Hochholzer, P., G. B. Lipford, H. Wagner, K. Pfeffer, and K. Heeg. 2000. Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect.Immun. 68:3502-3508.
9. Klaerner, H. G., U. Eschenbach, K. Kamereck, N. Lehn, H. Wagner, and T. Miethke. 2000. Failure of an automated blood culture system to detect nonfermentative gram-negative bacteria. J.Clin.Microbiol. 38:1036-1041.
10. Kranzer, K., M. Bauer, G. B. Lipford, K. Heeg, H. Wagner, and R. Lang. 2000. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-gamma production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type I and interleukin-12. IMM 99:170-178.
11. Krieg, A. M. and H. Wagner. 2000. Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA [In Process Citation]. Immunol.Today 21:521-526.
12. Lapatschek, M., S. Durr, R. Lower, C. Magin, H. Wagner, and T. Miethke. 2000. Functional analysis of the env open reading frame in human endogenous retrovirus IDDMK(1,2)22 encoding superantigen activity [In Process Citation]. J.Virol. 74:6386-6393.
13. Lipford, G. B., T. Sparwasser, S. Zimmermann, K. Heeg, and H. Wagner. 2000. CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J.Immunol. 165:1228-1235.
14. Lipford, G. B., S. Bendigs, K. Heeg, and H. Wagner. 2000. Poly-guanosine motifs costimulate antigen-reactive CD8 T cells while bacterial CpG-DNA affect T-cell activation via antigen-presenting cell-derived cytokines. IMM 101:46-52.
15. Sparwasser, T., R. M. Vabulas, B. Villmow, G. B. Lipford, and H. Wagner. 2000. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell independent cytotoxic T cell responses to soluble proteins. Eur.J.Immunol. 30:3591-3597.
16. Vabulas, R. M., H. Pircher, G. B. Lipford, H. Häcker, and H. Wagner. 2000. CpG-DNA activates in vivo T cell epitope presenting dendritic cells to trigger protective antiviral cytotoxic T cell responses. J.Immunol. 164:2372-2378.
17. Wagner, H., G. B. Lipford, and H. Häcker. 2000. The role of immunostimulatory CpG-DNA in septic shock. In Immunostimulatory DNA sequences (ISS), Vol. 22. E. Raz, ed. Springer Verlag, New York, pp. 167-172.
18. Wagner, H., H. Häcker, and G. B. Lipford. 2000. Immunostimulatory DNA sequences help to eradicate intracellular pathogens. In Immunostimulatory DNA Sequences (ISS), Vol. 22. E. Raz, ed. Springer Verlag, New York, pp. 147-152.
19. Weighardt, H., C. Feterowski, M. Veit, M. Rump, H. Wagner, and B. Holzmann. 2000. Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response [In Process Citation]. J.Immunol. 165:4537-4543.
20. Bauer, M., V. Redecke, J. W. Ellwart, B. Scherer, J. P. Kremer, H. Wagner, and G. B. Lipford. 2001. Bacterial CpG-DNA triggers activation and maturation of human CD11c-, CD123+ dendritic cells. J Immunol 166:5000-5007.
21. Bauer, S., C. J. Kirschning, H. Hacker, V. Redecke, S. Hausmann, S. Akira, H. Wagner, and G. B. Lipford. 2001. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc.Natl.Acad.Sci.U.S.A 98:9237-9242.
22. Biedermann, T., S. Zimmermann, H. Himmelrich, A. Gumy, O. Egeter, A. K. Sakrauskil, I. Seegmüller, H. Voigt, P. Launois, A. D. Levine, H. Wagner, K. Heeg, J. A. Lois, and M. Röcken. 2001. Interleukin 4 instructs Th1 responses and resistance to Leishmania major in susceptible BALB/c mice. Nat.Immunol. 2:1054-1060.
23. Lapatschek, M. S., S. Durr, G. Sutter, H. Wagner, and T. Miethke. 2001. Functional evaluation of HIV/SIV Nef as superantigen. Virology 282:329-337.
24. Neumann, F.-J., A. Kastrati, T. Miethke, G. Pogatsa-Murray, J. Mehilli, C. Valina, N. Jogethaei, C. P.da Costa, H. Wagner, and A. Schömig. 2001. Treatment of chlamydia pneumoniae infection with roxithromycin and effet on neointima proliferation after coronary stent placement (ISAR-3): a randomised, double-blind, placebocontrolled trial. The Lancet 357:2085-2089.
25. Prebeck, S., C. Kirschning, S. Durr, C. da Costa, B. Donath, K. Brand, V. Redecke, H. Wagner, and T. Miethke. 2001. Predominant role of toll-like receptor 2 versus 4 in Chlamydia pneumoniae-induced activation of dendritic cells. J Immunol 167:3316-3323.
26. Vabulas, R. M., P. Ahmad-Nejad, C. da Costa, T. Miethke, C. J. Kirschning, H. Hacker, and H. Wagner. 2001. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol.Chem. 276:31332-31339.
27. Wagner, H. 2001. Toll meets bacterial CpG-DNA. Immunity 14:499-502.
28. Werts, C., Tapping.R.I., J. C. Mathison, T.-H. Chuang, V. Kravchenko, I. S. Girons, D. A. Haake, P. J. Godowski, F. Hayashi, A. Ozinsky, D. M. Underhill, C. J. Kirschning, H. Wagner, A. Aderem, P. S. Tobias, and R. J. Ulevitch. 2001. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat.Immunol. 2:346-352.
29. Ahmad-Nejad, P., H. Häcker, M. Rutz, S. Bauer, R. M. Vabulas, and H. Wagner. 2002. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Europ.J.Immunol. 7:1958-1968.
30. Bauer, S. and H. Wagner. 2002. Bacterial CpG-DNA licenses TLR9. Curr.Top.Microbiol.Immunol 270:145-54.:145-154.
31. Bieback, K., E. Lien, I. M. Klagge, E. Avota, J. Schneider-Schaulies, W. P. Duprex, H. Wagner, C. J. Kirschning, M. Ter, V, and S. Schneider-Schaulies. 2002. Hemagglutinin protein of wild-type measles virus activates toll-like receptor 2 signaling. J Virol. 76:8729-8736.
32. Costa, C. P., C. J. Kirschning, D. Busch, S. Durr, L. Jennen, U. Heinzmann, S. Prebeck, H. Wagner, and T. Miethke. 2002. Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae. Eur.J Immunol 32:2460-2470.
33. Häcker, H., C. Fürmann, H. Wagner, and G. Häcker. 2002. Caspase-9/-3 activation and apoptosis are indued in mouse macrophages upon ingestion and digestion of Escherichia coli bacteria. J Immunol 169:3172-3179.
34. Hochrein, H., M. O'Keeffe, and H. Wagner. 2002. Human and mouse plasmacytoid dendritic cells. Hum.Immunol 63:1103-1110.
35. Jurk, M., F. Heil, J. Vollmer, C. Schetter, A. M. Krieg, H. Wagner, G. Lipford, and S. Bauer. 2002. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat.Immunol 3:499.
36. Knabel, M., T. J. Franz, M. Schiemann, A. Wulf, B. Villmow, B. Schmidt, H. Bernhard, H. Wagner, and D. H. Busch. 2002. Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nat.Med 8:631-637.
37. Lochner, M., H. Wagner, M. Classen, and I. Forster. 2002. Generation of neutralizing mouse anti-mouse IL-18 antibodies for inhibition of inflammatory responses in vivo. J Immunol Methods 259:149-157.
38. Maurer, T., A. Heit, H. Hochrein, F. Ampenberger, M. O'Keeffe, S. Bauer, G. B. Lipford, R. M. Vabulas, and H. Wagner. 2002. CpG-DNA aided cross-presentaton of soluble antigens by dendritic cells. Eur.J.Immunl. 32:2356-2364.
39. Rad, R., M. Gerhard, R. Lang, M. Schöniger, T. Rösch, W. Schepp, I. Becker, H. Wagner, and C. Prinz. 2002. The Helicobacter pylori blood group antigen-binding adhesin facilitates bacterial colonization and augments a nonspecific immune response. J.Immunol. 168:3033-3041.
40. Sethi, S., G. Lipford, H. Wagner, and H. Kretschmar. 2002. Postexposure prophylaxis against prion disease with a stimulator of innate immunity. Lancet 360:229-230.
41. Vabulas, R. M., P. Ahmad-Nejad, S. Ghose, C. Kirschning, R. Issels, and H. Wagner. 2002. HSP70 as endogenous stimulus of the Toll/Interleukin-1 receptor signal pathway. J Biol.Chem. 277:15107-15112.
42. Vabulas, R. M., H. Wagner, and H. Schild. 2002. Heat shock proteins as ligands of toll-like receptors. Curr.Top.Microbiol.Immunol 270:169-84.:169-184.
43. Vabulas, R. M., S. Braedel, N. Hilf, H. Singh-Jasuja, S. Herter, P. Ahmad-Nejad, C. J. Kirschning, C. da Costa, H. G. Rammensee, H. Wagner, and H. Schild. 2002. The endoplasmic reticulum-resident heat shock protein Gp96 activates dendritic cells via the Toll-like receptor 2/4 pathway. J Biol.Chem. 277:20847-20853.
44. Wagner, H. 2002. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr.Opin.Microbiol. 5:62-69.
45. Wallasch, C., J. E. Crabtree, D. Bevec, P. A. Robinson, H. Wagner, and A. Ullrich. 2002. Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem.Biophys.Res.Commun. 19;295:695-701.
46. Wallasch, C., J. E. Crabtree, D. Bevec, P. A. Robinson, H. Wagner, and A. Ullrich. 2002. Helicobacter pylori-stimulated EGF receptor transactivation requires metalloprotease cleavage of HB-EGF. Biochem.Biophys.Res.Commun. 19;295:695-701.
47. Weighardt, H., S. Kaiser-Moore, R. M. Vabulas, C. J. Kirschning, H. Wagner, and B. Holzmann. 2002. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol 169:2823-2827.
48. Alferink, J., I. Lieberam, W. Reindl, A. Behrens, S. Weiss, N. Huser, K. Gerauer, R. Ross, A. B. Reske-Kunz, P. Ahmad-Nejad, H. Wagner, and I. Forster. 2003. Compartmentalized Production of CCL17 In Vivo: Strong Inducibility in Peripheral Dendritic Cells Contrasts Selective Absence from the Spleen. J Exp.Med 197:585-599.
49. Haase, R., C. J. Kirschning, A. Sing, P. Schrottner, K. Fukase, S. Kusumoto, H. Wagner, J. Heesemann, and K. Ruckdeschel. 2003. A dominant role of Toll-like receptor 4 in the signaling of apoptosis in bacteria-faced macrophages. J Immunol 171:4294-4303.
50. Heil, F., P. Ahmad-Nejad, H. Hemmi, H. Hochrein, F. Ampenberger, T. Gellert, H. Dietrich, G. Lipford, K. Takeda, S. Akira, H. Wagner, and S. Bauer. 2003. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur.J Immunol 33:2987-2997.
29. Heit, A., T. Maurer, H. Hochrein, S. Bauer, K. M. Huster, D. H. Busch, and H. Wagner. 2003. Cutting Edge: Toll-Like Receptor 9 Expression Is Not Required for CpG DNA-Aided Cross-Presentation of DNA-Conjugated Antigens but Essential for Cross-Priming of CD8 T Cells. J Immunol 170:2802-2805.
51. Koedel, U., B. Angele, T. Rupprecht, H. Wagner, A. Roggenkamp, H. W. Pfister, and C. J. Kirschning. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J Immunol 170:438-444.
52. Lembo, A., C. Kalis, C. J. Kirschning, V. Mitolo, E. Jirillo, H. Wagner, C. Galanos, and M. A. Freudenberg. 2003. Differential contribution of Toll-like receptors 4 and 2 to the cytokine response to Salmonella enterica serovar Typhimurium and Staphylococcus aureus in mice. Infect Immun. 71:6058-6062.
53. Meier, A., C. J. Kirschning, T. Nikolaus, H. Wagner, J. Heesemann, and F. Ebel. 2003. Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol. 5:561-570.
54. Meng, G., A. Grabiec, M. Vallon, B. Ebe, S. Hampel, W. Bessler, H. Wagner, and C. J. Kirschning. 2003. Cellular recognition of tri-/di-palmitoylated peptides is independent from a domain encompassing the N-terminal seven leucine-rich repeat (LRR)/LRR-like motifs of TLR2. J Biol.Chem. 278:39822-39829.
55. Prazeres da Costa, C., H. Wagner, and T. Miethke. 2003. Heat shock protein-mediated activation of innate immune cells. In Heat Shock Proteins and Inflammation. W. Eden van, ed. Birkhäuser Verlag Basel, pp. 43-54.
56. Prazeres, d. C., F. J. Neumann, A. Kastrati, I. Stallforth, M. Schmid, N. Joghetai, S. Prebeck, H. Wagner, and T. Miethke. 2003. Role of IgG-seropositivity to Chlamydia pneumoniae in early thrombotic events after coronary stent placement. Atherosclerosis 166:171-176.
57. Prebeck, S., H. Brade, C. J. Kirschning, C. P. da Costa, S. Durr, H. Wagner, and T. Miethke. 2003. The Gram-negative bacterium Chlamydia trachomatis L(2) stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin. Microbes.Infect 5:463-470.
58. Seegmuller, I., H. Hacker, and H. Wagner. 2003. IL-4 regulates IL-12 p40 expression post-transcriptionally as well as via a promoter-based mechanism. Eur.J Immunol 33:428-433.
60. Sing, A., N. Tvardovskaia, D. Rost, C. J. Kirschning, H. Wagner, and J. Heesemann. 2003. Contribution of toll-like receptors 2 and 4 in an oral Yersinia enterocolitica mouse infection model. Int.J Med Microbiol. 293:341-348.
30. Spies, B., H. Hochrein, M. Vabulas, K. Huster, D. H. Busch, F. Schmitz, A. Heit, and H. Wagner. 2003. Vaccination with plasmid DNA activates dendritic cells via toll-like receptor 9 (TLR9) but functions in TLR9-deficient mice. J Immunol 171:5908-5912.
61. Anders, H. J., V. Vielhauer, V. Eis, Y. Linde, M. Kretzler, D. L. Perez, F. Strutz, S. Bauer, M. Rutz, H. Wagner, H. J. Grone, and D. Schlondorff. 2004. Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J. 2004 Jan 20 [Epub ahead of print]
62. De Wit, D., V. Olislagers, S. Goriely, F. Vermeulen, H. Wagner, M. Goldman, and F. Willems. 2004. Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns. Blood 103:1030-1032.
63. Heit, A., K. M. Huster, F. Schmitz, M. Schiemann, D. H. Busch, and H. Wagner. 2004. CpG-DNA Aided Cross-Priming by Cross-Presenting B Cells. J Immunol 172:1501-1507.
64. Rutz, M., J. Metzger, T. Gellert, P. Luppa, G. B. Lipford, H. Wagner, and S. Bauer. 2004. Chloroquine inhibits direct binding of Toll-like receptor 9 to CpG-DNA. Immunity under revision.
65. Vier, J., M. Gerhard, H. Wagner, and G. Hacker. 2004. Enhancement of death-receptor induced caspase-8-activation in the death-inducing signalling complex by uncoupling of oxidative phosphorylation. Mol.Immunol 40:661-670.

Professor Rudolf Balling

1. Faiella, A., Wernig, M., Consalez, G., Hostick, U., Hoffmann, C., Hustert, E., Boncinelli, E., Balling, R., & Nadeau, J.H. (2000). A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX gene expression. J. Mol. Human Genetics 9, 227-236.
2. Hrabé de Angelis, M. & Balling, R. (2000). Modelle für menschliche Erkrankungen: Der ENU-Maus-Mutagenese-Screen im Deutschen Humangenomprojekt. Biospektrum 6, 108-110.
3. Sewarto, D., Fuchs, H., Fella, C., Rathkolb, B., Pargent, W., Heffner, S., Wolf, E., Balling, R. & Hrabé de Angelis, M. (2000). Identification of genes with clinically relevant functions-The Munich ENU-mutagenesis project. Mamm. Genome 11, 507-510.
4. Rathkolb, B., Decker, T., Fuchs, H., Soewarto, D., Fella, C., Heffner, S., Pargent, W., Wanke, R., Balling, R., Hrabé de Angelis, M., Kolb, H. & Wolf, E. (2000). The Clinical-Chemical screen in the Munich ENU mouse mutagenesis project: Screening for clinically relevant phenotypes. Mamm.Genome 11, 543-546.
5. Rolinski, B., Arnecke, R., Dame, T., Kreischer, J., Olgemöller, B., Wolf, E., Balling, R., Hrabé de Angelis, M. & Roscher, A. (2000). The biochemical metabolite screen in the Munich ENU mouse mutagenesis project: determination of amino acids and acylcarnitines by tandem mass spectrometry. Mamm. Genome 11, 547-551.
6. Fuchs, H., Schughart, K., Wolf, E., Balling, R. & Hrabe de Angelis, M. (2000). Screening for dysmorphological abnormalities: a powerful tool to isolate new mouse mutants. Mamm. Genome 11, 528-530.
7. 96. Hrabé de Angelis, M., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jacob, T., Fuchs, E., Kolb, H., Kremmer, E., Behrend, H., Ring, J., Zimmer, A., Pfeffer, K., Schughart, K., Wolf, E. & Balling, R. (2000). Genome wide large scale production of mutant mice by ENU mutagenesis. Nature Genetics 25, 444-447.
8. Balling, R. & Erben, R. (2000). From parathyroid to thymus, via glial cells (Niews and Views). Nature Medicine 6, 860-861.
9. Balling, R. (2000). Why we treasure the mutants. Times Higher Educ. Suppl. 445, 28-29.
10. Balling, R. & Hrabe de Angelis (2000). From developmental biology to developmental toxicology. Ann. N.Y. Acad. Sci. 919, 239-245.
11. Nadeau, J., Balling, R., Barsh, G., Beier, D., Brown, S.D., Bucan, M., Camper, S., Carlson, G., Copeland, N., Fletcher,, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.L:,Hicks, G., Hrabe de Angelis, M., Jackson., I., Jacobs, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A., Rinchik, E.M., Rossant, J., Russell, L.B., Schimenti, J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W. & Zimmer, A. (2001). Sequence interpretation. Functional annotation of mouse genome sequences. Science 291, 1251-1255
12. Kiernan, A.E., Ahituv, N., Fuchs, H., Balling, R., Avraham, K.B., Steel, K.P., Hrabe de Angelis, M.(2001). The Notch ligand Jagged1 is requeired for inner ear sensory development. Proc. Natl. Acad. Sci. USA 98, 3873-3878.
13. Graw, J., Klopp, N., Loster, J., Soewarto, D., Fuchs, H., Becker-Follmann, J., Reis, A., Wolf, E., Balling, R. & Hrabe de Angelis, M. (2001). Ethylnitrosurea-induced mutations in mice leads to the expression of a novel protein in the eye and to dominant cataracts. Genetics 157, 1313-1320.
14. Santagati, F., Gerber, J.K., Blusch, J.H., Kokubu, C., Peters, H., Adamski, J., Werner, T., Balling, R. & Imai, K. (2001). Comparative analysis of the genomic organization of Pax9 and ist conserved physical association with Nkx2-9 in the human, mouse and pufferfish genome. Mamm. Genome 12, 232-237.
15. Alessandrini, F., Jacob, T., Wolf, A., Balling, R., Hrabe de Angelis, M., Ring, J. & Behrendt, H. (2001). ENU mouse mutagenesis: generation of mouse mutants with aberannt plasma IGE levels. Int. Arch. Allergy Immunol. 124, 25-28
16. Lengeling, A., Pfeffer, K. & Balling, R. (2001). The battle of two genomes: genetics of bacterial host/pathogen interactions in mice. Mamm. Genome 12, 261-271.
17. Brown S.D. & Balling, R. (2001). Systematic approaches to mouse mutagenesis. Curr. Opin. Genet. Dev. 11, 268-273.
18. Graw, J., Löster, J., Soewarto, D., Fuchs, H., Reis., A., Wolf, E., Balling, R. & Hrabé de Angelis, M. (2001). Aey2, a new mutation in the betaB.-crystallin-encoding gene of the mouse. Invest. Ophtalmol. Vis. Sci. 42, 1574-1580.
19. Graw, J., Löster, J., Soewarto, D., Fuchs, H., Meyer-B., Reis, A., Wolf, E., Balling, R. & Hrabé de Angelis, M. (2001). Characterization of a new, dominant V124E mutation in the mouse alpha-A-crystallin-encoding gene. Invest. Ophthalmol. Vis. Sci. 42, 2909-2915.
20. Balling, R. (2001). ENU mutagenesis: analyzing gene function in mice. Ann. Rev. Genomics Hum. Genet. 2, 463-492.
21. Graw, J., Löster, J. Soewarto, D., Fuchs, H., Meyer. B., Reis. A., Wolf, E., Balling, R. & Hrabé de Angelis (2001). Characterization of a mutation in the lens-specific MP70 encoding gene of the mouse leading to a dominant cataract. Exp. Eye Res. 73, 867-876.
22. Vreugde, S., Erven, A., Kros, C.J., Marcotti, W., Fuchs, H., Kurima, K., Wilcox, R.R., Friedman, T.B., Griffith, A.J., Balling, R., Hrabé de Angelis, M., Avraham, K.B. & Steel, K. (2002). Beethoven, a mouse model for dominant, progressive hearing loss DFNA 36. Nature Genet. 30, 257-258.
23. Kist, R. Schrewe, H. Balling, R. & Scherer, G. (2002). Conditional inactivation of Sox9: a mouse model for campomelic dysplasia. Genesis 32, 121-123
24. Hetzer-Egger, C., Schorpp, M., Haas-Assenbaum, A., Balling, R., Peters, H. & Böhm, (2002). Thymopoiesis requires Pax9 function in thymic epithelial cells. Eur. J. Immunol. 32, 1175-1181.
25. Schulz, H., Johner, C., Eder, G., Ziesenis, A., Reitmeier, P., Heyder, H. & Balling, R. (2002). Respiratory mechanics in mice: strain and sex specific differences. Acta Physiol. Scand. 174, 367-375.
26. Ernest, S., Christensen, B., Gilfix, B.M., Mamer, O.A., Hosack, A., Rodier, M., Comenares, C., McGrawth, J., Bale, A., Balling, R., Sankoff, D., Rosenblatt, D.S. & Nadeau, J.H. (2002). Genetics and molecular control of folate-homocysteine metabolism in mutant mice. Mamm. Genome 13, 259-267.
27. Erben RG, Soegiarto DW, Weber K, Zeitz U, Lieberherr M, Gniadecki R, Moller G, Adamski J, Balling R. (2002). Deletion of deoxyribonucleic acid binding domain of the vitamin D receptor abrogates genomic and nongenomic functions of vitamin D. Mol Endocrinol. 16, 1524-1537.
28. Gerber, J., Richter, T., Kremmer, E., Adamski, J., höfler, H., Balling, R. & Peters, H. (2002). Progressive loss of Pax9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus. J. Pathol. 197, 293-297.
29. Jansen WT, Bolm M, Balling R, Chhatwal GS, Schnabel R. (2002). Hydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes. Infect Immun. 70, 5202-5207.
30. Graw, J., Löster, J., Soewarto, D., Fuchs, H., Reis, A., Wolf, E., Balling, R., Hrabé de Angelis, M. (2002). V76D mutation in a conserved gD-crystallin region leads to dominant cataracts in Mice. Mamm. Genome 13, 452-455
31. Rodrigo, I., Hill, R.E., Balling, R., Münsterberg, A.& Imai, K. (2003). Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome. Development 130, 473-482.
32. Zeitz, U., Weber, K., Soegiarto, D.W., Wolf, E., Balling, R., Erben, R.G. (2003). Imapired insulin secretory capacity in mice lacking a functional vitamin D receptor. FASEB J. 17, 509-511.
33. Buer, J. & Balling, R. (2003). Mice, Microbes and Models of Infection. Nature Rev. Genet. 4, 195-205.
34. Rubio-Aliaga, I., Frey, I., Boll, B., Gronjeberg, D.A., Eichinger, H.M., Balling, R., Daniel, H. (2003). Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney. Mol. Cell Biol. 23, 3247-3252.
35. Stoeger, T., Proetzel, G.E., Welzel, H., Papadimitriou, A., Dony, C., Balling, R. & Hofmann, C. (2003). In situ gene expression analysis during BMP2-induced ectopic bone formation in mice shows simultaneous endochondral and intramembraneous ossification. Growth Factors 20, 197-210.
36. Wollscheid-Lengeling, E., Müller, R.J., Balling, R., Schughart, K. (2004). Maintaining your immune system--one method for enhanced longevity. Sci Aging Knowledge Environ., 2004(1): pe2., [PubMed - in process].

Dr. Thomas Häupl

1. Schultz O, Sittinger M, Häupl T, Burmester GR. Emerging strategies of bone and joint repair. Arthritis Res 2000;2:433-6.
2. Kaps C, Bramlage C, Smolian H, Haisch A, Ungethüm U, Burmester GR, Sittinger M, Gross G, Häupl T. Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum 2002;46:149-62.
3. Rosen O, Thiel A, Massenkeil G, Hiepe F, Häupl T, Radtke H, Burmester GR, Gromnica-Ihle E, Radbruch A, Arnold R. Autologous stem-cell transplantation in refractory autoimmune diseases after in vivo immunoablation and ex vivo depletion of mononuclear cells. Arthritis Res 2000;2:327-36.
4. Benjamin M, Bollow M, Claudepierre P, François R, Häupl T, Sittinger M, Gay S, Leirisalo-Repo M, Poole R. Anatomy and biochemistry of entheses. Ann Rheum Dis 2000;59:995-9.
5. Häupl T, Kaps C, Bramlage C, Ungethüm U, Gross G, Sittinger M, Burmester GR. Bone Morphogenetic Proteins: Regeneratoren und Protektoren für Gelenkknorpel? Z Rheumatol 2000;59:414-5.
6. Gross G, Czichos S, Ju W, Kaps C, Häupl T, Sittinger M, Burmester GR, Gazit D,Hoffmann A. Signalkaskaden bei der Knorpel- und Knochenbildung. Z Rheumatol 2000;59:406-7.
7. Sittinger M, Perka C, Schultz O, Wilke I, Mensing M, Gross G, Häupl T, Burmester GR. Neue Ansätze zur Knorpelregeneration durch Tissue Engineering bei chronischen Gelenkerkrankungen. Z Rheumatol 2000;59:410-1.
8. Ringe J, Kaps C, Schmitt B, Büscher K, Bartel J, Smolian H, Schultz O, Burmester GR, Häupl T, Sittinger M. Porcine mesenchymal stem cells: Induction of distinct mesenchymal cell lineages. Cell Tissue Res 2002;307:321-7.
9. Krenn V, Morawietz L, Häupl T, Neidel J, König A. Grading of chronic synovitis - a histopahtological grading system for molecular and diagnostic pathology. Path Res Pract 2002;accepted:
10. Häupl T, Burmester GR, Stuhlmüller B. New aspects of molecular biology diagnosis. Array technology and expression profile for characterization of rheumatic diseases. Z Rheumatol 2002;61:396-404.
11. Kaps C, Loch A, Haisch A, Smolian H, Burmester GR, Häupl T, Sittinger M. Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes. Med Biol Eng Comput 2002;40:485-90.
12. Burmester GR, Häupl T, Stuhlmüller B. Monocytes and Macrophages in Synovitis: Villains or Victims? Arthritis Res 2000;1:S15.
13. Ungethum U, Häupl T, Zacher J, Gursche A, Förster, Reutermann P, Pruß A, Krenn V,Burmester GR. Patterns of differentially expressed genes in synovial tissue from RA and OA patients and from normal joints. Arthritis Res 2001;3:P045.
14. Häupl T, Kaps C, Gross G, Burmester GR, Sittinger M. Engineered cells and cartilage healing. Arthritis Res 2001;3:P35.
15. Ungethum U, Häupl T, Koczan D, Huber H, v Helversen T, Ruiz P, Witt H, Drungowski M, Zacher J, Seyfert C, Neidel J, Krenn V, Burmester GR, Thiesen H-J, Lehrach H, Bläß S. RA-specific expression profiles and new candidate genes. Arthritis Res 2003;5:81.
16. Hernandez M, Martinez L, Kiesslich O, Tandon N, Janitz M, Lehrach H, Wagner F, Häupl T, Burmester GR, Stuhlmüller B. Influence of anti-TNF therapy on monocyte gene expression in rheumatoid arthritis. Arthritis Res Ther 2003;5:41.
17. Ringe J, Häupl T, Sittinger M. Mesenchymal stem cells for tissue engineering of bone and cartilage. Med Klin 2003;98:35-40.
18. Häupl T, Kaps C, Kiesslich O, Rohrlach T, Morawietz L, Neidel J, Pruss A, Krenn V, Gursche A, Zacher J, Radbruch A,Burmester GR. Synovial gene expression profiles in chronic joint diseases. Osteoarthritis Cartilage 2003;11:S101.
19. Hernandez M, Martinez L, Kiesslich O, Tandon N, Janitz M, Lehrach H, Wagner F, Häupl T, Burmester GR, Stuhlmüller B. Influence of anti-TNF therapy on monocyte gene expression in rheumatoid arthritis. Ann Rheum Dis 2003;62:180.
20. Krenn V, Petersen I, Morawietz L, Häupl T, Köpenick A, Dietel M, Konthur Z,Skriner K. Tissue arrays in proteomics. Path Res Pract 2004;in press:
21. Häupl T, Krenn V, Stuhlmüller B, Radbruch A, Burmester GR. Perspectives and limitations of gene expression profiling in rheumatology. Arthritis Res 2004;submitted:

Professor Andreas Radbruch

1. Pandiyan P, Gärtner D, Sözeri O, Radbruch A, Schulze-Osthoff K, Brunner-Weinzierl MC (2004). CD152 (CTLA-4) determines the unequal resistance of Th1 and Th2 cells against activation-induced cell death by a mechanism requiring PI3´kinase function. J. Exp. Med., in press.

2. Leipe J, Skapenko A, Niesner U, Devriendt K, Beetz R, Radbruch A, Kalden JR, Lipsky P, Schulze-Koops H. (2004). GATA-3 in human Th2 development. J Exp Med, in press

3. Rufenach C, Burmester G-R, Zeidler H, Radbruch A (2004). Kompetenznetz "Entzündlich-rheumatische Systemerkrankungen". Sonderheft "Der Internist" zur DGIM, 2004 (submitted)

4. Bartholome B, Spies CM, Gaber T, Schuchmann S, Berki T, Kunkel D, Bienert M, Radbruch A, Burmester G-R, Lauster R, Scheffold A, Buttgereit F. Membrane glucocorticoid receptors (mGCR) are expressed in normal human peripheral blood mononuclear cells and upregulated following in vitro stimulation and in patients with rheumatoid arthritis. FASEB J. 18 2004, 70-80.

5. Baumgrass R, Zhang Y, Erdmann F, Thiel A, Weiwad M, Radbruch A, Fischer G. Substitution in position 3 of cyclosporin A abolishes the cyclophilin-mediated gain-of-function mechanism but not immunosuppression. J Biol Chem. 2003 Oct 28. PMID: 14583619.

6. Luger E, Radbruch A (2003). Regulation der IgE-Expression. (review) Allergologie, Jahrgang 26, no 10, 440-445

7. Rajewsky K & Radbruch A (2003). The cellular basis of B cell memory. (Book Chapter). IN: The Molecular Biology of B Cells (Eds. Frederick W Alt, Tasuku Honjo, Michael S Neuberger). Elsevier Science, London.

8. Löhning M, Richter A, Stamm T, Hu-Li J, Assenmacher M, Paul WE, Radbruch A. Establishment of memory for IL-10 expression in developing T helper 2 cells requires repetitive IL-4 costimulation and does not impair proliferation. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12307-12. Epub 2003 Sep 26. PMID: 14514890

9. Maszyna F, Hoff H, Kunkel D, Radbruch A, Brunner-Weinzierl MC. Diversity of clonal T cell proliferation is mediated by differential expression of CD152 (CTLA-4) on the cell surface of activated individual T lymphocytes. J Immunol. 2003 Oct 1;171(7):3459-66. PMID: 14500641

10. Odendahl M, Keitzer R, Wahn U, Hiepe F, Radbruch A, Dörner T, Bunikowski R. Perturbations of peripheral B lymphocyte homoeostasis in children with systemic lupus erythematosus. Ann Rheum Dis. 2003 Sep;62(9):851-8. PMID: 12922958

11. Cassese G, Arce S, Hauser AE, Lehnert K, Moewes B, Mostarac M, Muehlinghaus G, Szyska M, Radbruch A, Manz RA. Plasma cell survival is mediated by synergistic effects of cytokines and adhesion-dependent signals. J Immunol. 2003 Aug 15;171(4):1684-90. PMID: 12902466

12. Kunkel D, Kirchhoff D, Volkmer-Engert R, Radbruch A, Scheffold A. Sensitive visualization of peptide presentation in vitro and ex vivo. Cytometry. 2003 Jul;54A(1):19-26. PMID: 12820117 [PubMed - in process].

13. Jacobi AM, Odendahl M, Reiter K, Bruns A, Burmester GR, Radbruch A, Valet G, Lipsky P, Dörner T. Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 2003 May;48(5):1332-42. PMID: 12746906.

14. Kunkel D, Kirchhoff D, Nishikawa S, Radbruch A, Scheffold A. Visualization of peptide presentation following oral application of antigen in normal and Peyer's patches-deficient mice. Eur J Immunol. 2003 May;33(5):1292-301. PMID: 12731054.

15. Zou J, Zhang Y, Thiel A, Rudwaleit M, Shi SL, Radbruch A, Poole R, Braun J, Sieper J. Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis. Rheumatology (Oxford). 2003 Jul;42(7):846-55. Epub 2003 Feb 28. PMID: 12730543

16. Löhning M, Hutloff A, Kallinich T, Mages HW, Bonhagen K, Radbruch A, Hamelmann E, Kroczek RA. Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med. 2003 Jan 20;197(2):181-93. PMID: 12538658.

17. Hauser AE, Mühlinghaus G, Manz RA, Cassese G, Arce S, Debes GF, Hamann A, Berek C, Lindenau S, Dörner T, Hiepe F, Odendahl M, Riemekasten G, Krenn V, Radbruch A. Long-lived plasma cells in immunity and inflammation. Ann N Y Acad Sci. 2003 Apr;987:266-9. Review. No abstract available. PMID: 12727650.

18. Lindenau S, Scholze S, Odendahl M, Dörner T, Radbruch A, Burmester GR, Berek C. Aberrant activation of B cells in patients with rheumatoid arthritis. Ann N Y Acad Sci. 2003 Apr;987:246-8. Review. No abstract available. PMID: 12727646

19. Wagner B, Radbruch A, Rohwer J, Leibold W. Monoclonal anti-equine IgE antibodies with specificity for different epitopes on the immunoglobulin heavy chain of native IgE. Vet Immunol Immunopathol. 2003 Mar 20;92(1-2):45-60. PMID: 12628763

20. Riemekasten G, Langnickel D, Ebling FM, Karpouzas G, Kalsi J, Herberth G, Tsao BP, Henklein P, Langer S, Burmester GR, Radbruch A, Hiepe F, Hahn BH. Identification and characterization of SmD183-119-reactive T cells that provide T cell help for pathogenic anti-double-stranded DNA antibodies. Arthritis Rheum. 2003 Feb;48(2):475-85. PMID: 12571858.

21. Arce S, Cassese G, Hauser A, Dörner T, Odendahl M, Manz R, Radbruch A, Hiepe F. The role of long-lived plasma cells in autoimmunity. Immunobiology. 2002 Dec;206(5):558-62. Review. PMID: 12607731.

22. Schneider S, Bruns A, Möwes B, Holzknecht B, Hausdorf G, Riemekasten G, Radbruch A, Hiepe F, Thiel A. Simultaneous cytometric analysis of (auto)antigen-reactive T and B cell proliferation. Immunobiology. 2002 Dec;206(5):484-95. PMID: 12607723.

23. Wagner B, Siebenkotten G, Leibold W, Radbruch A. Expression of a 4-(hydroxy-3-nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivo. Equine Vet J. 2002 Nov;34(7):657-65. PMID: 12455835.